Muscle, endocrine, and immunological markers of frailty in older people

To analyze muscle, endocrine, and immunological markers that influence frailty in older people assisted in primary care. Cross-sectional, analytical, and probabilistic study were linked to the institutional research “Integrated Health Care for Older People.” The study population consisted of males a...

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Bibliographic Details
Published in:Experimental gerontology 2021-08, Vol.151, p.111405-111405, Article 111405
Main Authors: Pillatt, Ana Paula, Silva, Brenda Da, Franz, Ligia Beatriz Bento, Berlezi, Evelise Moraes, Schneider, Rodolfo Herberto
Format: Article
Language:English
Subjects:
Biomarkers
Diagnosis
Endocrine system
Frail elderly
Immune system
Musculoskeletal system
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Summary:To analyze muscle, endocrine, and immunological markers that influence frailty in older people assisted in primary care. Cross-sectional, analytical, and probabilistic study were linked to the institutional research “Integrated Health Care for Older People.” The study population consisted of males and females aged 60 years or more and assisted in primary health care. The research protocol included an interview and physical examination to evaluate the frailty criteria. Analysis of the following were done: serum calcium and creatinine as muscle markers; vitamin D, parathyroid hormone, and insulin-like growth factor − 1 as endocrine markers; and interleukin-6, C-reactive protein, leukocytes, and neutrophil-lymphocyte ratio as immunological markers. Statistical analysis included the Mann–Whitney test to compare means, and linear regression to analyze the relationship between dependent and independent variables. There was a relationship between creatinine and prediction of weight loss (p 
ISSN:0531-5565
1873-6815
DOI:10.1016/j.exger.2021.111405