Venovenous versus venoarterial extracorporeal membrane oxygenation among infants with hypoxic-ischemic encephalopathy: is there a difference in outcome?

Our hypothesis was that among infants with hypoxic-ischemic encephalopathy (HIE), venoarterial (VA), compared to venovenous (VV), extracorporeal membrane oxygenation (ECMO) is associated with an increased risk of mortality or intracranial hemorrhage (ICH). Retrospective cohort analysis of infants in...

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Bibliographic Details
Published in:Journal of perinatology 2021-08, Vol.41 (8), p.1916-1923
Main Authors: Agarwal, Prashant, Natarajan, Girija, Sullivan, Kevin, Rao, Rakesh, Rintoul, Natalie, Zaniletti, Isabella, Keene, Sarah, Mietzsch, Ulrike, Massaro, An N, Billimoria, Zeenia, Dirnberger, Daniel, Hamrick, Shannon, Seabrook, Ruth B, Weems, Mark F, Cleary, John P, Gray, Brian W, DiGeronimo, Robert
Format: Article
Language:English
Subjects:
Blood oxygenation, Extracorporeal
Brain
Brain damage
Child
Cohort Studies
Diseases
Encephalopathy
Extracorporeal Membrane Oxygenation
Gestational age
Hemorrhage
Humans
Hypoxia
Hypoxia-Ischemia, Brain - therapy
Infant
Infant, Newborn
Infants
Infants (Newborn)
Intracranial Hemorrhages
Ischemia
Membranes
Mortality
Neonates
Oxygenation
Patient outcomes
Retrospective Studies
Risk factors
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Summary:Our hypothesis was that among infants with hypoxic-ischemic encephalopathy (HIE), venoarterial (VA), compared to venovenous (VV), extracorporeal membrane oxygenation (ECMO) is associated with an increased risk of mortality or intracranial hemorrhage (ICH). Retrospective cohort analysis of infants in the Children's Hospitals Neonatal Database from 2010 to 2016 with moderate or severe HIE, gestational age ≥36 weeks, and ECMO initiation
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-021-01089-4