Incidence of enterovirus in patients with acute gastroenteritis

Enteroviruses (EV) have been linked to lymphocytic meningitis and exanthems, but they may also be involved in acute gastroenteritis (AGE), a condition whose aetiological agent often remains unidentified. In this work 1214 samples from individuals with AGE were studied with the aim of establishing th...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2021-10, Vol.40 (10), p.2185-2190
Main Authors: Pérez-Martínez, Z., Álvarez-Argüelles, M. E., Rojo-Alba, S., Castello-Abietar, C., Boga, J. A., Morilla-Morilla, A., Vivanco-Allende, A., Rodríguez-Suárez, J., Alonso-Álvarez, M. A., Melón, S.
Format: Article
Language:English
Subjects:
Adenoviruses
Age
Biomedical and Life Sciences
Biomedicine
Child
Child, Preschool
Coinfection - epidemiology
Coinfection - virology
Enterovirus - classification
Enterovirus - genetics
Enterovirus - isolation & purification
Enterovirus - physiology
Enterovirus Infections - epidemiology
Enterovirus Infections - virology
Enteroviruses
Feces - virology
Female
Gastroenteritis
Gastroenteritis - epidemiology
Gastroenteritis - virology
Genotype
Humans
Infant
Infections
Internal Medicine
Male
Medical Microbiology
Meningitis
Original Article
Phylogeny
Viral Load
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Enteroviruses (EV) have been linked to lymphocytic meningitis and exanthems, but they may also be involved in acute gastroenteritis (AGE), a condition whose aetiological agent often remains unidentified. In this work 1214 samples from individuals with AGE were studied with the aim of establishing the incidence of EV. The samples were collected between September and December in three different years and subjected to real-time genomic amplification in order to determine the viral load (VL). Of the 1214 samples studied, infection by a single virus was found in 328 cases (27%) and coinfection in 69 (5.7%). While adenoviruses (AdV) were the most frequent (14.8% of total), EV were present in 126 (10.4%) of the individuals tested. Of the 126 EV-positive samples, this virus was found as a single infection and coinfection in 76 (6.3%) and 50 (4.1%) cases, respectively. VL for EV was 5.58±1.51 log copies/ml (range 3.73–9.69) in the former and 6.27±1.75 (range 3.73–10.5) (p=0.02) in the latter. EV were identified in 97 children under 5 (16.9%) and in 29 (4.5%) patients over 5. Patients less than 5 years showed a higher VL that those more than 5 years age [6.08±1.57 (range 3.82–9.69) vs. 5.07±1.53 (range 3.73–10.58); (p=0.002)]. There was a high incidence of EV in AGE patients, and they were more frequent in those under 5, where they were found to replicate more efficiently. These results therefore indicate that testing for EV should be included in the diagnosis of AGE.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-021-04275-6