Early-phase migration dynamics of Echinococcus multilocularis in two mouse strains showing different infection susceptibilities

[Display omitted] •Echinococcus multilocularis migration in mice was evaluated using parasite-specific quantitative PCR.•Oncospheres invaded mainly from the middle of the small intestine and completed migration to the liver within 24 h p.i.•Parasite load in small intestine and liver was lower in res...

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Published in:International journal for parasitology 2021-10, Vol.51 (11), p.893-898
Main Authors: Hayashi, Naoki, Kouguchi, Hirokazu, Imasato, Yuhei, Irie, Takao, Yagi, Kinpei, Nonaka, Nariaki, Nakao, Ryo
Format: Article
Language:English
Subjects:
Echinococcus multilocularis
Migration dynamics
Oncospheres
Primary alveolar echinococcosis
qPCR
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Summary:[Display omitted] •Echinococcus multilocularis migration in mice was evaluated using parasite-specific quantitative PCR.•Oncospheres invaded mainly from the middle of the small intestine and completed migration to the liver within 24 h p.i.•Parasite load in small intestine and liver was lower in resistant mouse strain C57BL/6 than susceptible mouse strain DBA/2.•Parasite invasion of the intestine may be a critical stage regulating susceptibility to E. multilocularis infection in mice. The early-phase migration dynamics of Echinococcus multilocularis in the intermediate hosts remain largely unknown. We compared the parasite burden in the intestine, liver and faeces of DBA/2 and C57BL/6 mouse strains using parasite-specific quantitative PCR. Our results indicated that the parasites invaded mainly from the middle segments of the small intestine and completed migration to the liver within 24 h p.i. C57BL/6 mice had lower parasite DNA burdens in the intestine and liver but higher in the faeces than DBA/2 mice, suggesting that parasite invasion of the intestine may be a critical stage regulating susceptibility to E. multilocularis infection in mice.
ISSN:0020-7519
1879-0135
DOI:10.1016/j.ijpara.2021.04.001