Cancer cells relax and resist cytotoxic attack

When it comes to cancer evading the immune response, antigen presentation usually gets all the attention. In this issue of Immunity, Tello-Lafoz et al. reveal that cancer cells have another card up their sleeve: by regulating gene expression to "soften" their actin cytoskeleton, cancer cel...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2021-05, Vol.54 (5), p.853-855
Main Authors: Usmani, Shariq M, Mempel, Thorsten R
Format: Article
Language:English
Subjects:
Actin
Actin Cytoskeleton
Animals
Antigen Presentation
Antigens
Apoptosis
Breast cancer
Cancer
Cytoskeleton
Cytotoxicity
Gene expression
HIV
Human immunodeficiency virus
Humans
Immune response
Immune system
Immunotherapy
Ligands
Lymphocytes
Melanoma
Metastasis
Neoplasms
Polymerization
Proteins
Viruses
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Summary:When it comes to cancer evading the immune response, antigen presentation usually gets all the attention. In this issue of Immunity, Tello-Lafoz et al. reveal that cancer cells have another card up their sleeve: by regulating gene expression to "soften" their actin cytoskeleton, cancer cells limit susceptibility to lymphocyte-mediated cytotoxic attack.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2021.04.017