Understanding Opioid Actions, Pain and Analgesia: A Tribute to Dr. Gavril Pasternak

This special issue is a tribute to our mentor, colleague and friend, Gavril W. Pasternak, MD, PhD. Homage to the breadth and depth of his work (~ 450 publications) over a 40 career in pharmacology and medicine cannot be captured fully in one special issue, but the 22 papers collected herein represen...

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Bibliographic Details
Published in:Cellular and molecular neurobiology 2021-07, Vol.41 (5), p.827-834
Main Authors: Standifer, Kelly M., Inturrisi, Charles E., Foley, Kathleen M., Pan, Ying-Xian
Format: Article
Language:English
Subjects:
Addictions
Alternative splicing
Analgesia
Analgesics
Biomedical and Life Sciences
Biomedicine
Cell Biology
Commentary
Drug tolerance
Narcotics
Neurobiology
Neurosciences
Opioid receptors
Pain perception
Pasternak
Withdrawal
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Summary:This special issue is a tribute to our mentor, colleague and friend, Gavril W. Pasternak, MD, PhD. Homage to the breadth and depth of his work (~ 450 publications) over a 40 career in pharmacology and medicine cannot be captured fully in one special issue, but the 22 papers collected herein represent seven of the topics near and dear to Gav’s heart, and the colleagues, friends and mentees who held him near to theirs. The seven themes include: (1) sites and mechanisms of opioid actions in vivo; (2) development of novel analgesic agents; (3) opioid tolerance, withdrawal and addiction: mechanisms and treatment; (4) opioid receptor splice variants; (5) novel research tools and approaches; (6) receptor signaling and crosstalk in vitro; and (7) mentorship. This introduction to the issue summarizes contributions and includes formal and personal remembrances of Gav that illustrate his personality, warmth, and dedication to making a difference in patient care and people’s lives.
ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-021-01097-0