Skeletal muscle cellular contractile dysfunction after anterior cruciate ligament reconstruction contributes to quadriceps weakness at 6‐month follow‐up

Muscle dysfunction following anterior cruciate ligament reconstruction (ACLR) may evolve from alterations in muscle contractility at the myofilament protein level. Using a prospective, within‐subject case–control design, we evaluated cellular‐level contractility, cross‐sectional area (CSA), and myos...

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Bibliographic Details
Published in:Journal of orthopaedic research 2022-03, Vol.40 (3), p.727-737
Main Authors: Tourville, Timothy W., Voigt, Thomas B., Choquette, Rebecca H., Failla, Mathew J., Endres, Nathan K., Slauterbeck, James R., Beynnon, Bruce D., Toth, Michael J.
Format: Article
Language:English
Subjects:
Anterior Cruciate Ligament Injuries
Anterior Cruciate Ligament Reconstruction - adverse effects
Female
Follow-Up Studies
Humans
knee/ACL
Male
Muscle Fibers, Skeletal
muscle physiology
Muscle Strength - physiology
posttraumatic osteoarthritis
Prospective Studies
Quadriceps Muscle
Quality of Life
strength loss
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Summary:Muscle dysfunction following anterior cruciate ligament reconstruction (ACLR) may evolve from alterations in muscle contractility at the myofilament protein level. Using a prospective, within‐subject case–control design, we evaluated cellular‐level contractility, cross‐sectional area (CSA), and myosin heavy chain (MHC) isoform expression on single muscle fibers 3 weeks post ACLR, and evaluated their relationship to whole muscle strength and patient‐oriented outcomes 6 months post operation. Biopsies of the vastus lateralis were performed 3 weeks post ACLR in 11 subjects (5 females, mean age ± SD = 24.7 ± 6.5 years, height = 172.7 ± 8.2 cm, mass = 75.7 ± 12.5 kg) following first‐time ACL rupture and whole muscle strength and self‐reported pain, function, and quality of life assessed 6 months post ACLR. At 3 weeks post ACLR, force production was reduced (p 
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.25065