Effect of preoperative potassium iodide administration on Graves’ disease surgery: a propensity score analysis

Preoperative administration of a saturated solution of potassium iodide (SSKI) is recommended in the guidelines for the management of hyperthyroidism due to Graves’ disease. Studies addressing its effect on complications after thyroidectomy are inconclusive. Retrospective multicenter Propensity Scor...

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Bibliographic Details
Published in:The American journal of surgery 2021-11, Vol.222 (5), p.959-963
Main Authors: Barranquero, Alberto G, Muñoz de Nova, José Luis, Gómez-Ramírez, Joaquín, Valdés de Anca, Álvaro, Porrero, Belén, Blanco Terés, Lara, Corral, Sara, Martín-Pérez, Elena
Format: Article
Language:English
Subjects:
Age
Bias
Complications
Disease
Female
Graves Disease - drug therapy
Graves Disease - surgery
Graves' disease
Hematoma
Humans
Hyperthyroidism
Hypoparathyroidism
Iodides
Length of stay
Lugol
Male
Middle Aged
Normal distribution
Paralysis
Patients
Postoperative
Potassium
Potassium iodide
Potassium Iodide - therapeutic use
Potassium iodides
Preoperative Care - methods
Propensity Score
Retrospective Studies
Statistical analysis
Surgeons
Surgery
Surgical outcomes
Thyroid gland
Thyroidectomy
Thyroidectomy - adverse effects
Thyroidectomy - methods
Variables
Vitamin D
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Summary:Preoperative administration of a saturated solution of potassium iodide (SSKI) is recommended in the guidelines for the management of hyperthyroidism due to Graves’ disease. Studies addressing its effect on complications after thyroidectomy are inconclusive. Retrospective multicenter Propensity Score study of patients undergoing total thyroidectomy for Graves’ disease, from January 2013 to September 2019 in two tertiary centers in Madrid, Spain. Patients were given SSKI prior to surgery or not according to surgeons’ preferences. Electronic clinical records were reviewed searching: baseline characteristics surgical variables, pathological findings, and postoperative complications. Ninety patients were analyzed: 44 received SSKI and 46 were not given SSKI. No significant differences were found in the main postoperative complications with or without SSKI: transient hypoparathyroidism (40.9% vs. 50%), permanent hypoparathyroidism (6.8% vs. 13%), transient recurrent laryngeal nerve (RLN) palsy (2.3% vs. 8.7%), definitive RLN palsy (2.3% vs. 2.2%), or cervical hematoma (2.3% vs. 4.3%). Preoperative administration of SSKI had no impact on postoperative complications after thyroidectomy for Graves’ disease. •The preoperative administration of potassium iodide is currently recommended.•The impact of SSKI on Graves’ disease thyroidectomy was evaluated.•No differences were found on the main postoperative complications.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2021.04.023