Nanostructured lipid carriers containing chitosan or sodium alginate for co-encapsulation of antioxidants and an antimicrobial agent for potential application in wound healing

The high incidence and costs of chronic wounds in the elderly have motivated the search for innovations to improve product performance and the healing process while reducing costs. In this study, bioadhesive nanostructured lipid carriers (NLC) were developed for the co-encapsulation of compounds wit...

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Bibliographic Details
Published in:International journal of biological macromolecules 2021-07, Vol.183, p.668-680
Main Authors: Costa-Fernandez, Sandra, Matos, Jenyffer K.R., Scheunemann, Gaby S., Salata, Giovanna C., Chorilli, Marlus, Watanabe, Il-Sei, de Araujo, Gabriel L.B., Santos, Marinilce F., Ishida, Kelly, Lopes, Luciana B.
Format: Article
Language:English
Subjects:
Antimicrobial
Antioxidants
Bioadhesion
Nanostructured lipid carriers
Wound healing
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Summary:The high incidence and costs of chronic wounds in the elderly have motivated the search for innovations to improve product performance and the healing process while reducing costs. In this study, bioadhesive nanostructured lipid carriers (NLC) were developed for the co-encapsulation of compounds with antioxidant (α-tocopherol and quercetin) and antimicrobial (tea tree oil) activity for management of wounds. The NLC was produced with shea butter and argan oil, and modified with sodium alginate or chitosan to confer bioadhesive properties. Spherical nanoparticles of ~307–330 nm and zeta potential varying from −21.2 to +11.8 mV were obtained. Thermal analysis demonstrated that the lipid matrix reduced tea tree oil thermal loss (~1.8-fold). Regardless of the type of polysaccharide employed, the NLCs promoted cutaneous localization of antioxidants in damaged (subjected to incision) skin, with a ~74 to 180-fold higher delivery into the skin compared to percutaneous delivery. This result is consistent with the similar bioadhesive properties of chitosan or sodium alginate-modified NLC. Nanoencapsulation of tea tree oil did not preclude its antimicrobial effects against susceptible and resistant strains of S. aureus and P. aeruginosa, while co-encapsulation of antioxidants increased the NLC-induced fibroblasts migration, supporting their potential usefulness for management of wounds. •Developed shea butter and argan oil-based nanostructured lipid carriers (NLC)•Coating with chitosan (Ch) or sodium alginate (Al) conferred opposite charges•Encapsulation of tea tree oil reduced its thermal loss and did not preclude antimicrobial effects•Regardless of the polysaccharide, NLC provided cutaneous targeting•NLC increased fibroblast migration, and antioxidants encapsulation intensified the effect.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2021.04.168