Reparative Perineural Hyperplasia in the Gastric Wall: A Histologic Mimic of Perineural Invasion

Reparative perineural hyperplasia is an incidental and probably underreported reactive histologic finding thus far only reported in the setting of healing wounds or adjacent to a dermatofibroma in cutaneous specimens. It is characterized by a focal concentric proliferation of cytologically bland spi...

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Bibliographic Details
Published in:International journal of surgical pathology 2021-12, Vol.29 (8), p.903-905
Main Authors: Bošnjak, Matic, Kojc, Nika
Format: Article
Language:English
Subjects:
Aged
Diagnosis, Differential
Digestive system
Female
Gastrectomy
Gastroscopy
Humans
Hyperplasia
Hyperplasia - diagnosis
Hyperplasia - etiology
Hyperplasia - pathology
Hyperplasia - surgery
Immunohistochemistry
Neoplasm Invasiveness
Peripheral Nerves - pathology
Stomach - innervation
Stomach - pathology
Stomach - surgery
Stomach Neoplasms - diagnosis
Stomach Ulcer - complications
Stomach Ulcer - diagnosis
Stomach Ulcer - pathology
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Description
Summary:Reparative perineural hyperplasia is an incidental and probably underreported reactive histologic finding thus far only reported in the setting of healing wounds or adjacent to a dermatofibroma in cutaneous specimens. It is characterized by a focal concentric proliferation of cytologically bland spindled perineurial cells and is hence considered a benign histologic mimic of neoplastic perineural invasion. Thus, it may present a diagnostic pitfall and we therefore consider it as a valuable entity to be aware of. To the best of our knowledge, this brief case report is the first to convey that reparative perineural hyperplasia may also occur in the gastrointestinal tract. It may therefore be a ubiquitous reactive histological phenomenon relating to previous surgical or traumatic wounds in various sites, that is, outside the thus far established setting of skin reexcision specimens.
ISSN:1066-8969
1940-2465
DOI:10.1177/10668969211013469