Decreased expression of programmed death-1 on CD8+ effector memory T lymphocytes correlates with the pathogenesis of type 1 diabetes

Aims Chronic inflammation of autoimmune diseases, including type 1 diabetes (T1D), is mainly mediated by memory T(Tm) cells, predominantly effector memory T (Tem) cells. The roles of the programmed death-1 (PD-1) receptor on lymphocytes have been well studied in tumor and other infection models. How...

Full description

Saved in:
Bibliographic Details
Published in:Acta diabetologica 2021-09, Vol.58 (9), p.1239-1249
Main Authors: Shan, Yimei, Kong, Yinghong, Zhou, Yan, Guo, Jingjing, Shi, Qiyun, Li, Sicheng, Guo, Heming, Huang, Yiting, Ding, Sisi, Liu, Cuiping, Cao, Lei, Huang, Yun, Fang, Chen, Hu, Ji
Format: Article
Language:English
Subjects:
Apoptosis
Autoantibodies
Autoimmune diseases
Autoimmunity
CD8 antigen
Diabetes
Diabetes mellitus (insulin dependent)
Effector cells
Flow cytometry
Immunological memory
Inflammation
Internal Medicine
Leukocytes (mononuclear)
Lymphocytes T
Medicine
Medicine & Public Health
Memory cells
Metabolic Diseases
Original Article
Pathogenesis
PD-1 protein
PD-L1 protein
Peptides
Peripheral blood mononuclear cells
Spleen
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims Chronic inflammation of autoimmune diseases, including type 1 diabetes (T1D), is mainly mediated by memory T(Tm) cells, predominantly effector memory T (Tem) cells. The roles of the programmed death-1 (PD-1) receptor on lymphocytes have been well studied in tumor and other infection models. However, little is known about the relationship between the expression of PD-1 on CD8 + Tem cells and the pathogenesis of T1D. Methods A total of 52 patients diagnosed with T1D and 39 gender-, age-, and ethnically matched health control individuals were enrolled in this study. Peripheral blood mononuclear cells from these individuals were isolated and analyzed by flow cytometry. We evaluated the frequencies of PD-1 + CD8 + memory T cell subsets from patients' peripheral blood with T1D and the spleen cells of nonobese diabetic (NOD) mice in the present study. We also investigated the effects of blocking PD-1/PD-L1 pathway on islet’s inflammation in NOD mice. Results Frequencies of PD-1 + CD8 + Tem cells were decreased significantly in PBMC of patients with T1D (40.73 ± 12.72 vs 47.43 ± 15.56, * p  
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-021-01711-z