Objective assessment of Platelet‐Rich Plasma (PRP) potentiality in the treatment of Chronic leg Ulcer: RCT on 80 patients with Venous ulcer

Background Chronic venous leg ulcer reduces the patients’ activities and their overall quality of life. Platelet‐rich plasma (PRP) was previously investigated as promising less invasive management for leg ulcers. This study aims To re‐assess the efficacy and safety of PRP in the management of chroni...

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Bibliographic Details
Published in:Journal of cosmetic dermatology 2021-10, Vol.20 (10), p.3257-3263
Main Authors: Helmy, Yasser, Farouk, Nehal, Ali Dahy, Asmaa, Abu‐Elsoud, Ahmed, Fouad khattab, Rania, Elshahat Mohammed, Sahar, Abdullbary Gad, Lamia, Altramsy, Ayman, Hussein, Emad, Farahat, Ayman
Format: Article
Language:English
Subjects:
chronic ulcers
healing process
leg
platelet rich plasma
venous
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Summary:Background Chronic venous leg ulcer reduces the patients’ activities and their overall quality of life. Platelet‐rich plasma (PRP) was previously investigated as promising less invasive management for leg ulcers. This study aims To re‐assess the efficacy and safety of PRP in the management of chronic leg ulcers due to venous factors. Patients/Methods RCT enrolled 80 patients who clinically presented with chronic venous leg ulcers. Forty patients were allocated randomly for the treatment with autologous platelet‐rich plasma (PRP). Intradermal and subdermal injection of PRP by 27guage syringe weekly, in all edges and in the granular floor of the ulcer for 4–6 sessions. Another 40 patients managed by conventional treatment by compression and dressing for the same period were allocated as Group B. Objective assessment achieved by the percentage of reduction of the size of the ulcer area, rate of healing, incidence of recurrence, and if side effects have been reported. Results PRP therapy showed better results and high p value significance when compared to conventional therapy. Conclusion This study shows that PRP is effective and significant in promoting the wound healing process in chronic leg venous ulcers. PRP is simple, safe, and has a short learning curve technique.
ISSN:1473-2130
1473-2165
DOI:10.1111/jocd.14138