Translating the Transcriptome: Sex Differences in the Mechanisms of Depression and Stress, Revisited

The past decade has produced a plethora of studies examining sex differences in the transcriptional profiles of stress and mood disorders. As we move forward from accepting the existence of extensive molecular sex differences in the brain to exploring the purpose of these sex differences, our approa...

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Bibliographic Details
Published in:Biological psychiatry (1969) 2022-01, Vol.91 (1), p.25-35
Main Authors: Rainville, Jennifer R., Lipuma, Timothy, Hodes, Georgia E.
Format: Article
Language:English
Subjects:
Brain
Depression
Depression - genetics
Epigenetics
Female
Humans
Male
Mood Disorders
RNA sequencing
Sex Characteristics
Sex chromosome complement
Sex differences
Stress
Transcriptome
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Summary:The past decade has produced a plethora of studies examining sex differences in the transcriptional profiles of stress and mood disorders. As we move forward from accepting the existence of extensive molecular sex differences in the brain to exploring the purpose of these sex differences, our approach must become more systemic and less reductionist. Earlier studies have examined specific brain regions and/or cell types. To use this knowledge to develop the next generation of personalized medicine, we need to comprehend how transcriptional changes across the brain and/or the body relate to each other. We provide an overview of the relationships between baseline and depression/stress-related transcriptional sex differences and explore contributions of preclinically identified mechanisms and their impacts on behavior.
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2021.02.003