Sleep disorders as a possible predisposing attack factor in neuromyelitis optica spectrum disorder (NMOSD): A case-control study

Sleep disturbances are common in neuromyelitis optica spectrum disorder (NMOSD) and have a great impact on patients’ quality of life. According to a report, there is a 64% prevalence of poor sleep quality in NMOSD patients. Therefore, this study was done to evaluate the effect of sleep disturbances...

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Published in:Clinical neurology and neurosurgery 2021-05, Vol.204, p.106606-106606, Article 106606
Main Authors: Haji Molla Rabi, Samaneh, Shahmirzaei, Shaghayegh, Sahraian, Mohammad Ali, Kazemi Mozdabadi, Razieh Sadat, Rezaei Aliabadi, Hossein, Gheini, Mohammad Reza, Majidi, Fazeleh, Naser Moghadasi, Abdorreza
Format: Article
Language:English
Subjects:
Adult
Age
Alzheimer's disease
Anxiety
Attack
Case-Control Studies
Female
Gender differences
Humans
Latency
Male
Medical research
Middle Aged
Neuromyelitis
Neuromyelitis Optica - complications
Neuromyelitis optica spectrum disorder
Quality of Life
Questionnaires
Remission
Restless legs syndrome
Sleep
Sleep disorder
Sleep disorders
Sleep Wake Disorders - complications
Young Adult
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Summary:Sleep disturbances are common in neuromyelitis optica spectrum disorder (NMOSD) and have a great impact on patients’ quality of life. According to a report, there is a 64% prevalence of poor sleep quality in NMOSD patients. Therefore, this study was done to evaluate the effect of sleep disturbances on NMOSD acute exacerbations. This case-control study was conducted at Sina Hospital in 2019. A total of 60 patients with NMOSD diagnosis were enrolled in the study (30 patients were in the remission phase while 30 patients were hospitalized due to acute attacks). Sleep disorders were evaluated in both groups. Sleep quality was assessed during the last month using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Data were analyzed by SPSS software version 21. Among 60 patients who were evaluated in both the control and attack groups, 86.7% were female. The duration of the disease was 68.23 ± 42.89 months in the control group and 69.83 ± 6.90 in the attack group. The mean age of patients was 34.15 years old. Sleep quality was unfavorable in 30% and 56% of patients in control and attack groups, respectively. There were significant differences between the two groups in sleep latency, habitual sleep efficiency, sleep duration, and sleep disturbance. The present study revealed that there was a significant difference in sleep quality between controls and attack patients and could show a direct relationship between sleep disorders and NMOSD attacks. •Sleep disturbances are common in neuromyelitis optica spectrum disorder (NMOSD).•This study was done to evaluate the effect of sleep disturbances on NMOSD acute exacerbations.•There was a significant difference in sleep quality between controls and attack patients.•This finding could show a direct relationship between sleep disorders and NMOSD attacks.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2021.106606