On the association between circulating biomarkers and atherosclerotic calcification in a cohort of arterial disease participants

Atherosclerotic calcification is a powerful predictor of cardiovascular disease. This study aims to determine whether circulating levels of a local/systemic calcification inhibitor or a marker of bone formation correlate with measures of coronary or extracoronary calcification. Clinical computed tom...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2021-05, Vol.31 (5), p.1533-1541
Main Authors: Cahalane, Rachel M., Barrett, Hilary E., Ross, Aisling M., Mulvihill, John J.E., Purtill, Helen, Selvarajah, Logeswaran, O'Brien, Julie, Kavanagh, Eamon G., Moloneye, Michael A., Egan, Siobhan M., Leahy, Fiona C., Griffin, Tomás P., Islam, M.N., O'Shea, Paul M., Walsh, Michael T., O'Connor, Eibhlís M.
Format: Article
Language:English
Subjects:
Aged
alpha-2-HS-Glycoprotein - analysis
Biomarkers - blood
Calcium-Binding Proteins - blood
Cardiovascular disease
Carotid Artery Diseases - blood
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - surgery
Computed tomography
Computed Tomography Angiography
Coronary Angiography
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Diagnostic testing
Endarterectomy, Carotid
Extracellular Matrix Proteins - blood
Female
Fetuin-A
Humans
Lower Extremity - blood supply
Male
Matrix Gla Protein
Middle Aged
Osteocalcin
Osteocalcin - blood
Peripheral Arterial Disease - blood
Peripheral Arterial Disease - diagnosis
Peripheral Arterial Disease - surgery
Plaque, Atherosclerotic
Predictive Value of Tests
Vascular Calcification - blood
Vascular Calcification - diagnostic imaging
Vascular Calcification - surgery
X-Ray Microtomography
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Summary:Atherosclerotic calcification is a powerful predictor of cardiovascular disease. This study aims to determine whether circulating levels of a local/systemic calcification inhibitor or a marker of bone formation correlate with measures of coronary or extracoronary calcification. Clinical computed tomography (CT) was performed on 64 arterial disease participants undergoing carotid and lower extremity endarterectomy. Coronary artery calcium (CAC) scores and volumes were acquired from the CT scans (n = 42). CAC scores and volumes were used to derive CAC density scores. Micro-CT was performed on excised carotid (n = 36) and lower extremity (n = 31) plaques to quantify the volume and volume fraction of extracoronary calcification. Circulating levels of dephospho-uncarboxylated Matrix Gla Protein (dp-ucMGP), fetuin-A, carboxylated and uncarboxylated osteocalcin (ucOC) were quantified using commercial immunoassays. Carotid participant CAC density scores were moderately negatively correlated with plasma dp-ucMGP (rs = −0.592, P = 0.008). A weak negative association was found between CAC scores and %ucOC for all participants (rs = −0.335, P = 0.040). Another weak negative correlation was observed between fetuin-A and the volume of calcification within excised carotid specimens (rs = −0.366, P = 0.031). Despite substantial differences in coronary and extracoronary calcium measurements, the levels of circulating biomarkers did not vary significantly between carotid and lower extremity subgroups. Correlations identified between circulating biomarkers and measures of coronary and extracoronary calcium were not consistent among participant subgroups. Further research is required to determine the association between circulating biomarkers, coronary and extracoronary calcium. •Dp-ucMGP is negatively correlated with coronary calcium density in carotid endarterectomy group.•Uncarboxylated osteocalcin is negatively associated with coronary calcium scores.•Fetuin-A is negatively correlated with the volume of carotid plaque calcification.•Coronary and extracoronary calcium measures are significantly different between carotid/lower extremity endarterectomy groups.•Levels of biomarkers tested are not significantly different between carotid/lower extremity endarterectomy groups.
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2021.02.005