Functional NK surrogate biomarkers for inflammatory recurrent pregnancy loss and recurrent implantation failure

Problem Expansion of circulating NK cells has been related to pregnancy complications. This study aims at investigating several surface NK cell markers to identify a baseline inflammatory profile in women with recurrent pregnancy loss (iRPL) and recurrent implantation failure (iRIF). Method of study...

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Published in:American journal of reproductive immunology (1989) 2021-08, Vol.86 (2), p.e13426-n/a
Main Authors: Comins‐Boo, Alejandra, Cristóbal, Ignacio, Fernández‐Arquero, Miguel, Rodríguez de Frías, Edgard, Calvo Urrutia, Marta, Pilar Suárez, Lydia, Gasca Escorial, Pilar, Ángel Herráiz, Miguel, Sánchez‐Ramón, Silvia
Format: Article
Language:English
Subjects:
Abortion
Abortion, Habitual - blood
Abortion, Habitual - immunology
Adult
Antigens, Differentiation - blood
Antigens, Differentiation - immunology
Biomarkers
Biomarkers - blood
Cell surface
cytotoxic NK cells
Cytotoxicity
Embryo Implantation
Female
Humans
Immunomodulation
Implantation
Inflammation
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Natural killer cells
NKp30
Patients
Peripheral blood
Phenotyping
Pregnancy
Pregnancy complications
recurrent implantation failure
recurrent pregnancy loss
T‐cell immunoglobulin and ITIM domain
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Summary:Problem Expansion of circulating NK cells has been related to pregnancy complications. This study aims at investigating several surface NK cell markers to identify a baseline inflammatory profile in women with recurrent pregnancy loss (iRPL) and recurrent implantation failure (iRIF). Method of study Expression of NKp30, TIGIT, NKp46, and DNAM‐1 on total peripheral blood NK subsets, regulatory (CD56brightCD16neg), and cytotoxic (CD56dimCD16pos/neg) NK cells was measured. Results Eighty‐three women were recruited and classified into two groups, 58 women with RPL and 25 with RIF. A control group of 31 fertile women was included. Expression of NKp30 on cytNK was significantly higher in RPL (p = .019) and RIF (p 
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.13426