Varicella Zoster Viral Retinitis following Chimeric Antigenic Response T-cell Therapy for B-cell Lymphoma

To describe the first case of varicella zoster virus (VZV) retinitis following chimeric antigenic response (CAR) T-cell therapy. Case review. A 53-year-old male was treated with CAR T-cell therapy for refractory diffuse large B-cell lymphoma. Nine months after CAR T-cell therapy, he developed VZV sk...

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Bibliographic Details
Published in:Ocular immunology and inflammation 2022-08, Vol.30 (6), p.1447-1448
Main Authors: Alsarhani, Waleed K., Abu El-Asrar, Ahmed M.
Format: Article
Language:English
Subjects:
B-cell
Chimeric antigenic response T-cell therapy
lymphoma
retinitis
varicella zoster virus
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Summary:To describe the first case of varicella zoster virus (VZV) retinitis following chimeric antigenic response (CAR) T-cell therapy. Case review. A 53-year-old male was treated with CAR T-cell therapy for refractory diffuse large B-cell lymphoma. Nine months after CAR T-cell therapy, he developed VZV skin infection and retinitis. The retinitis responded to systemic acyclovir therapy and intravitreal ganciclovir. VZV retinitis can occur following CAR T-cell immunotherapy.
ISSN:0927-3948
1744-5078
DOI:10.1080/09273948.2021.1889611