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Diagnostic performance of the Kaiser score for characterizing lesions on breast MRI with comparison to a multiparametric classification system
•The Kaiser score has high diagnostic accuracy in breast magnetic resonance imaging.•The interobserver agreement for the Kaiser score was excellent.•The use of the Kaiser score may reduce the biopsy rate for true negative lesions. To determine the diagnostic performance of the Kaiser score and to co...
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| Published in: | European journal of radiology 2021-05, Vol.138, p.109659-109659, Article 109659 |
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| container_end_page | 109659 |
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| container_title | European journal of radiology |
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| creator | Istomin, Aleksandr Masarwah, Amro Vanninen, Ritva Okuma, Hidemi Sudah, Mazen |
| description | •The Kaiser score has high diagnostic accuracy in breast magnetic resonance imaging.•The interobserver agreement for the Kaiser score was excellent.•The use of the Kaiser score may reduce the biopsy rate for true negative lesions.
To determine the diagnostic performance of the Kaiser score and to compare it with the BI-RADS–based multiparametric classification system (MCS).
Two breast radiologists, blinded to the clinical and pathological information, separately evaluated a database of 499 consecutive patients with structural 3.0 T breast MRI and 697 histopathologically verified lesions. The Kaiser scores and corresponding MCS categories were recorded. The sensitivity and specificity of the Kaiser score and the MCS categories to differentiate benign from malignant lesions were calculated. The interobserver reproducibility and receiver operating characteristic (ROC) parameters were analysed.
The sensitivity and specificity of the MCS were 100 % and 12 %, respectively, and those of the Kaiser score were 98.5 % and 34.8 % for reader 1 and 98.7 % and 47.5 % for reader 2. The area under the ROC-curve was 85.9 and 87.6 for readers 1 and 2. The interobserver intraclass correlation coefficient was excellent at 0.882. Reader 1 upgraded six lesions from BI-RADS 3 to a Kaiser score of >4, and reader 2 upgraded seven lesions. When applying the Kaiser score to 158 benign lesions readers 1 and 2 would have reduced the biopsy rate by 22.8 % and 35.4 %, respectively.
The Kaiser score showed high diagnostic accuracy with excellent interobserver reproducibility. The MCS had perfect sensitivity but low specificity. Although the Kaiser score had slightly lower sensitivity, its specificity was 3–4 times greater than that of the MCS. Thus, the Kaiser score has the potential to considerably reduce the biopsy rate for true negative lesions. |
| doi_str_mv | 10.1016/j.ejrad.2021.109659 |
| format | article |
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To determine the diagnostic performance of the Kaiser score and to compare it with the BI-RADS–based multiparametric classification system (MCS).
Two breast radiologists, blinded to the clinical and pathological information, separately evaluated a database of 499 consecutive patients with structural 3.0 T breast MRI and 697 histopathologically verified lesions. The Kaiser scores and corresponding MCS categories were recorded. The sensitivity and specificity of the Kaiser score and the MCS categories to differentiate benign from malignant lesions were calculated. The interobserver reproducibility and receiver operating characteristic (ROC) parameters were analysed.
The sensitivity and specificity of the MCS were 100 % and 12 %, respectively, and those of the Kaiser score were 98.5 % and 34.8 % for reader 1 and 98.7 % and 47.5 % for reader 2. The area under the ROC-curve was 85.9 and 87.6 for readers 1 and 2. The interobserver intraclass correlation coefficient was excellent at 0.882. Reader 1 upgraded six lesions from BI-RADS 3 to a Kaiser score of >4, and reader 2 upgraded seven lesions. When applying the Kaiser score to 158 benign lesions readers 1 and 2 would have reduced the biopsy rate by 22.8 % and 35.4 %, respectively.
The Kaiser score showed high diagnostic accuracy with excellent interobserver reproducibility. The MCS had perfect sensitivity but low specificity. Although the Kaiser score had slightly lower sensitivity, its specificity was 3–4 times greater than that of the MCS. Thus, the Kaiser score has the potential to considerably reduce the biopsy rate for true negative lesions.</description><identifier>ISSN: 0720-048X</identifier><identifier>EISSN: 1872-7727</identifier><identifier>DOI: 10.1016/j.ejrad.2021.109659</identifier><identifier>PMID: 33752000</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>BI-RADS ; Breast - diagnostic imaging ; Breast cancer ; Breast Neoplasms - diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Multiparametric MRI ; Radiography ; Reproducibility of Results ; Retrospective Studies ; ROC Curve ; Scoring system ; Sensitivity and Specificity</subject><ispartof>European journal of radiology, 2021-05, Vol.138, p.109659-109659, Article 109659</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-a413d148717cd00ca2ace9520fe5ec758a8b68723fe15570b60a50a764fffb8d3</citedby><cites>FETCH-LOGICAL-c404t-a413d148717cd00ca2ace9520fe5ec758a8b68723fe15570b60a50a764fffb8d3</cites><orcidid>0000-0001-5325-2699 ; 0000-0003-2423-9350 ; 0000-0001-8749-1268</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33752000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Istomin, Aleksandr</creatorcontrib><creatorcontrib>Masarwah, Amro</creatorcontrib><creatorcontrib>Vanninen, Ritva</creatorcontrib><creatorcontrib>Okuma, Hidemi</creatorcontrib><creatorcontrib>Sudah, Mazen</creatorcontrib><title>Diagnostic performance of the Kaiser score for characterizing lesions on breast MRI with comparison to a multiparametric classification system</title><title>European journal of radiology</title><addtitle>Eur J Radiol</addtitle><description>•The Kaiser score has high diagnostic accuracy in breast magnetic resonance imaging.•The interobserver agreement for the Kaiser score was excellent.•The use of the Kaiser score may reduce the biopsy rate for true negative lesions.
To determine the diagnostic performance of the Kaiser score and to compare it with the BI-RADS–based multiparametric classification system (MCS).
Two breast radiologists, blinded to the clinical and pathological information, separately evaluated a database of 499 consecutive patients with structural 3.0 T breast MRI and 697 histopathologically verified lesions. The Kaiser scores and corresponding MCS categories were recorded. The sensitivity and specificity of the Kaiser score and the MCS categories to differentiate benign from malignant lesions were calculated. The interobserver reproducibility and receiver operating characteristic (ROC) parameters were analysed.
The sensitivity and specificity of the MCS were 100 % and 12 %, respectively, and those of the Kaiser score were 98.5 % and 34.8 % for reader 1 and 98.7 % and 47.5 % for reader 2. The area under the ROC-curve was 85.9 and 87.6 for readers 1 and 2. The interobserver intraclass correlation coefficient was excellent at 0.882. Reader 1 upgraded six lesions from BI-RADS 3 to a Kaiser score of >4, and reader 2 upgraded seven lesions. When applying the Kaiser score to 158 benign lesions readers 1 and 2 would have reduced the biopsy rate by 22.8 % and 35.4 %, respectively.
The Kaiser score showed high diagnostic accuracy with excellent interobserver reproducibility. The MCS had perfect sensitivity but low specificity. Although the Kaiser score had slightly lower sensitivity, its specificity was 3–4 times greater than that of the MCS. Thus, the Kaiser score has the potential to considerably reduce the biopsy rate for true negative lesions.</description><subject>BI-RADS</subject><subject>Breast - diagnostic imaging</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Multiparametric MRI</subject><subject>Radiography</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Scoring system</subject><subject>Sensitivity and Specificity</subject><issn>0720-048X</issn><issn>1872-7727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UcFu1DAQtRCIbgtfgIR85JLFdpw4OXBALS0VRUgIJG7WxBl3vUrixeMFtR_Rb8ZlS4-cRjPzZp7ee4y9kmIthWzfbte4TTCulVCyTPq26Z-wleyMqoxR5ilbCaNEJXT344gdE22FEI3u1XN2VNemUaVdsbuzANdLpBwc32HyMc2wOOTR87xB_gkCYeLkYkJeltxtIIHLmMJtWK75hBTiQjwufEgIlPnnr5f8d8gb7uK8gxSorHLkwOf9lEOZwIw5FTY3AVHwwUEuLzjdUMb5BXvmYSJ8-VBP2PfzD99OP1ZXXy4uT99fVU4LnSvQsh6l7ow0bhTCgQKHfZHksUFnmg66oS1G1B5l0xgxtAIaAabV3vuhG-sT9ubwd5fizz1StnMgh9MEC8Y9WdUIXWtR675A6wPUpUiU0NtdCjOkGyuFvQ_Cbu3fIOx9EPYQRLl6_UCwH2YcH2_-OV8A7w4ALDJ_BUyWXMBi_RgSumzHGP5L8AdtwJ3C</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Istomin, Aleksandr</creator><creator>Masarwah, Amro</creator><creator>Vanninen, Ritva</creator><creator>Okuma, Hidemi</creator><creator>Sudah, Mazen</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5325-2699</orcidid><orcidid>https://orcid.org/0000-0003-2423-9350</orcidid><orcidid>https://orcid.org/0000-0001-8749-1268</orcidid></search><sort><creationdate>202105</creationdate><title>Diagnostic performance of the Kaiser score for characterizing lesions on breast MRI with comparison to a multiparametric classification system</title><author>Istomin, Aleksandr ; Masarwah, Amro ; Vanninen, Ritva ; Okuma, Hidemi ; Sudah, Mazen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-a413d148717cd00ca2ace9520fe5ec758a8b68723fe15570b60a50a764fffb8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>BI-RADS</topic><topic>Breast - diagnostic imaging</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Multiparametric MRI</topic><topic>Radiography</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Scoring system</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Istomin, Aleksandr</creatorcontrib><creatorcontrib>Masarwah, Amro</creatorcontrib><creatorcontrib>Vanninen, Ritva</creatorcontrib><creatorcontrib>Okuma, Hidemi</creatorcontrib><creatorcontrib>Sudah, Mazen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Istomin, Aleksandr</au><au>Masarwah, Amro</au><au>Vanninen, Ritva</au><au>Okuma, Hidemi</au><au>Sudah, Mazen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic performance of the Kaiser score for characterizing lesions on breast MRI with comparison to a multiparametric classification system</atitle><jtitle>European journal of radiology</jtitle><addtitle>Eur J Radiol</addtitle><date>2021-05</date><risdate>2021</risdate><volume>138</volume><spage>109659</spage><epage>109659</epage><pages>109659-109659</pages><artnum>109659</artnum><issn>0720-048X</issn><eissn>1872-7727</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>•The Kaiser score has high diagnostic accuracy in breast magnetic resonance imaging.•The interobserver agreement for the Kaiser score was excellent.•The use of the Kaiser score may reduce the biopsy rate for true negative lesions.
To determine the diagnostic performance of the Kaiser score and to compare it with the BI-RADS–based multiparametric classification system (MCS).
Two breast radiologists, blinded to the clinical and pathological information, separately evaluated a database of 499 consecutive patients with structural 3.0 T breast MRI and 697 histopathologically verified lesions. The Kaiser scores and corresponding MCS categories were recorded. The sensitivity and specificity of the Kaiser score and the MCS categories to differentiate benign from malignant lesions were calculated. The interobserver reproducibility and receiver operating characteristic (ROC) parameters were analysed.
The sensitivity and specificity of the MCS were 100 % and 12 %, respectively, and those of the Kaiser score were 98.5 % and 34.8 % for reader 1 and 98.7 % and 47.5 % for reader 2. The area under the ROC-curve was 85.9 and 87.6 for readers 1 and 2. The interobserver intraclass correlation coefficient was excellent at 0.882. Reader 1 upgraded six lesions from BI-RADS 3 to a Kaiser score of >4, and reader 2 upgraded seven lesions. When applying the Kaiser score to 158 benign lesions readers 1 and 2 would have reduced the biopsy rate by 22.8 % and 35.4 %, respectively.
The Kaiser score showed high diagnostic accuracy with excellent interobserver reproducibility. The MCS had perfect sensitivity but low specificity. Although the Kaiser score had slightly lower sensitivity, its specificity was 3–4 times greater than that of the MCS. Thus, the Kaiser score has the potential to considerably reduce the biopsy rate for true negative lesions.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>33752000</pmid><doi>10.1016/j.ejrad.2021.109659</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-5325-2699</orcidid><orcidid>https://orcid.org/0000-0003-2423-9350</orcidid><orcidid>https://orcid.org/0000-0001-8749-1268</orcidid><oa>free_for_read</oa></addata></record> |
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| source | ScienceDirect Journals |
| subjects | BI-RADS Breast - diagnostic imaging Breast cancer Breast Neoplasms - diagnostic imaging Humans Magnetic Resonance Imaging Multiparametric MRI Radiography Reproducibility of Results Retrospective Studies ROC Curve Scoring system Sensitivity and Specificity |
| title | Diagnostic performance of the Kaiser score for characterizing lesions on breast MRI with comparison to a multiparametric classification system |
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