Race disparities in genetic alterations within Wilms tumor specimens

Wilms tumor (WT) affects Black children disproportionately. Genetic aberrations within WT specimens that contribute to this disparity have not been reported. The Therapeutically Applied Research to Generate Effective Treatments (TARGET) database was queried for WT patient and genomic features. Clini...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pediatric surgery 2021-06, Vol.56 (6), p.1135-1141
Main Authors: Apple, Annie N, Neuzil, Kevin E, Phelps, Hannah M, Li, Bingshan, Lovvorn III, Harold N
Format: Article
Language:English
Subjects:
ACTB
DGCR8
DICER1
TARGET database
Wilms tumor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Wilms tumor (WT) affects Black children disproportionately. Genetic aberrations within WT specimens that contribute to this disparity have not been reported. The Therapeutically Applied Research to Generate Effective Treatments (TARGET) database was queried for WT patient and genomic features. Clinical and genetic variables were compared by race. Within the discovery set (enriched for adverse events; N = 94 White, 19 Black, 14 Other/unreported patients), Black children were more likely to present with advanced stage disease (p = 0.019). Within the validation set (primarily a random sampling of NWTS-5; N = 360 White, 92 Black, 72 Other/Unreported), Black children appeared older at diagnosis (p = 0.050), had decreased median follow-up time (p
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2021.02.030