Lactic acid bacteria prevent both periodontitis and atherosclerosis exacerbated by periodontitis in spontaneously hyperlipidemic mice

Background and Objective Recent studies have shown a link between periodontal disease and cardiovascular disease. We have previously reported that oral administration of Porphyromonas gingivalis (Pg) accelerates atherosclerosis in apolipoprotein E‐deficient spontaneously hyperlipidemic (Apoeshl) mic...

Full description

Saved in:
Bibliographic Details
Published in:Journal of periodontal research 2021-08, Vol.56 (4), p.753-760
Main Authors: Kobayashi, Ryoki, Hashizume‐Takizawa, Tomomi, Kurita‐Ochiai, Tomoko
Format: Article
Language:English
Subjects:
Alveolar bone
Aorta
Apolipoprotein E
Arteriosclerosis
Atherosclerosis
Bacteria
Bone loss
Cardiovascular diseases
Carnitine
Cytokines
Dentistry
Gum disease
Histidine
Inflammation
Intestinal microflora
Intestine
Intubation
Lactic acid
Lactic acid bacteria
Oral administration
Periodontal diseases
Periodontitis
Porphyromonas gingivalis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Objective Recent studies have shown a link between periodontal disease and cardiovascular disease. We have previously reported that oral administration of Porphyromonas gingivalis (Pg) accelerates atherosclerosis in apolipoprotein E‐deficient spontaneously hyperlipidemic (Apoeshl) mice. This study evaluated the potential of lactic acid bacteria (LAB) to change the intestinal flora changes induced by periodontopathic bacteria and to prevent/slow down the development of atherosclerosis. Methods Lactobacillus gasseri O3‐2 (Lg) was orally intubated in Apoeshl mice for 5 weeks. Three weeks after oral intubation, the mice were orally infected with Pg for 2 weeks. Results Thirty days after the last infection with Pg, Lg+Pg‐treated mice showed a significant reduction in alveolar bone loss compared to the Pg‐treated group. The Lg treatment restored the Pg‐induced intestinal flora disturbance to normal. Furthermore, a significant decrease in atherosclerotic plaque lesion size and suppressed inflammatory cytokine production in the aorta were detected in the Lg + Pg‐treated group. In contrast, blood concentrations of TMAO, histidine, and carnitine were enhanced by the Lg treatment but decreased by Lg + Pg treatment. Conclusion These results suggest that oral Lg treatment is effective in preventing periodontitis and atherosclerosis.
ISSN:0022-3484
1600-0765
DOI:10.1111/jre.12874