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Mechanistic insights of snake venom disintegrins in cancer treatment
Snake venoms are a potential source of various enzymatic and non-enzymatic compounds with a defensive role for the host. Various peptides with significant medicinal properties have been isolated and characterized from these venoms. Few of these are FDA approved. They inhibit tumor cells adhesion, mi...
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| Published in: | European journal of pharmacology 2021-05, Vol.899, p.174022-174022, Article 174022 |
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| Main Authors: | , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c362t-e015f094b47dbb6438bf43a4aa084cf7b49f9a7b439c96ab8876cc542e0038d53 |
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| cites | cdi_FETCH-LOGICAL-c362t-e015f094b47dbb6438bf43a4aa084cf7b49f9a7b439c96ab8876cc542e0038d53 |
| container_end_page | 174022 |
| container_issue | |
| container_start_page | 174022 |
| container_title | European journal of pharmacology |
| container_volume | 899 |
| creator | Akhtar, Bushra Muhammad, Faqir Sharif, Ali Anwar, Muhammad Irfan |
| description | Snake venoms are a potential source of various enzymatic and non-enzymatic compounds with a defensive role for the host. Various peptides with significant medicinal properties have been isolated and characterized from these venoms. Few of these are FDA approved. They inhibit tumor cells adhesion, migration, angiogenesis and metastasis by inhibiting integrins on transmembrane cellular surfaces. This plays important role in delaying tumor growth, neovascularization and development. Tumor targeting and smaller size make them ideal candidates as novel therapeutic agents for cancer treatment. This review is based on sources of these disintegrins, their targeting modality, classification and underlying anti-cancer potential.
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| doi_str_mv | 10.1016/j.ejphar.2021.174022 |
| format | article |
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| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 2021-05, Vol.899, p.174022-174022, Article 174022 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Angiogenic Animals Anti-cancer Antineoplastic Agents - adverse effects Antineoplastic Agents - isolation & purification Antineoplastic Agents - therapeutic use Disintegrins - adverse effects Disintegrins - isolation & purification Disintegrins - therapeutic use Humans Integrins Integrins - antagonists & inhibitors Integrins - metabolism Metastasis Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Peptides Signal Transduction Snake Venoms - metabolism |
| title | Mechanistic insights of snake venom disintegrins in cancer treatment |
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