Mechanistic insights of snake venom disintegrins in cancer treatment

Snake venoms are a potential source of various enzymatic and non-enzymatic compounds with a defensive role for the host. Various peptides with significant medicinal properties have been isolated and characterized from these venoms. Few of these are FDA approved. They inhibit tumor cells adhesion, mi...

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Bibliographic Details
Published in:European journal of pharmacology 2021-05, Vol.899, p.174022-174022, Article 174022
Main Authors: Akhtar, Bushra, Muhammad, Faqir, Sharif, Ali, Anwar, Muhammad Irfan
Format: Article
Language:English
Subjects:
Angiogenic
Animals
Anti-cancer
Antineoplastic Agents - adverse effects
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - therapeutic use
Disintegrins - adverse effects
Disintegrins - isolation & purification
Disintegrins - therapeutic use
Humans
Integrins
Integrins - antagonists & inhibitors
Integrins - metabolism
Metastasis
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Peptides
Signal Transduction
Snake Venoms - metabolism
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Summary:Snake venoms are a potential source of various enzymatic and non-enzymatic compounds with a defensive role for the host. Various peptides with significant medicinal properties have been isolated and characterized from these venoms. Few of these are FDA approved. They inhibit tumor cells adhesion, migration, angiogenesis and metastasis by inhibiting integrins on transmembrane cellular surfaces. This plays important role in delaying tumor growth, neovascularization and development. Tumor targeting and smaller size make them ideal candidates as novel therapeutic agents for cancer treatment. This review is based on sources of these disintegrins, their targeting modality, classification and underlying anti-cancer potential. [Display omitted]
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2021.174022