Ni-Catalyzed Carboxylation of Aziridines en Route to β‑Amino Acids

A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO2 at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access β-amino aci...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2021-04, Vol.143 (13), p.4949-4954
Main Authors: Davies, Jacob, Janssen-Müller, Daniel, Zimin, Dmitry P, Day, Craig S, Yanagi, Tomoyuki, Elfert, Jonas, Martin, Ruben
Format: Article
Language:English
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Summary:A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO2 at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access β-amino acids, important building blocks with considerable potential as peptidomimetics.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.1c01916