Retrospective comparison of results for simultaneous orders for LDL particle count, apolipoprotein B, and LDL-C

•LDL particle count (LDL-PNUM) by NMR show a strong correlation to LDL-C and apoB.•LDL-PNUM by NMR tends to classify more patients as high CVD risk vs. LDL-C or apoB.•In general, LDL-PNUM changes over time are similar to changes in LDL-C and apoB. Analysis of lipoprotein size and composition by nucl...

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Bibliographic Details
Published in:Clinica chimica acta 2021-07, Vol.518, p.38-42
Main Authors: Kroner, Grace M., Yuzyuk, Tatiana N., Zuromski, Lauren M., Johnson, Lisa M.
Format: Article
Language:English
Subjects:
apoB
Cardiovascular risk
LDL-C
LDL-particle
Lipoprotein
NMR
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Summary:•LDL particle count (LDL-PNUM) by NMR show a strong correlation to LDL-C and apoB.•LDL-PNUM by NMR tends to classify more patients as high CVD risk vs. LDL-C or apoB.•In general, LDL-PNUM changes over time are similar to changes in LDL-C and apoB. Analysis of lipoprotein size and composition by nuclear magnetic resonance (NMR) has been advocated as a method for identifying individuals at high CVD risk. We compared risk stratification between NMR-based LDL particle number (LDL-PNUM), LDL-cholesterol (LDL-C), and apolipoprotein B (apoB). Retrospective data from patients with simultaneous orders for LDL-PNUM, LDL-C, and apoB were analyzed and included data from an NMR assay (Numares). Quantitative and qualitative analyses were performed. Additional lipid parameters were investigated for patients with discordant risk classifications in LDL-related measurements. The percent change of LDL-PNUM was compared to the percent change of LDL-C or apoB for patients with serial measurements. We observed good quantitative and qualitative correlation when comparing LDL-PNUM to either LDL-C or apoB (Spearman’s ρ ≥ 0.83, percent agreements ≥ 85%). Among the patients with discordant risk stratification, most had increased LDL-PNUM and normal LDL-C and apoB. For patients with serial measurements, a strong correlation between the LDL-PNUM percent change and the LDL-C or apoB percent change was observed (Spearman’s ρ > 0.93). For many patients, risk stratification of LDL-PNUM is similar to apoB or LDL-C using cut-offs proposed by guidelines.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2021.03.004