High serum miR-421 is associated with metabolic dysregulation and inflammation in patients with metabolic syndrome

To explore the association of circulating miRNAs with adiposity, metabolic status and inflammatory biomarkers in patients with metabolic syndrome (MetS). Serum levels of 372 miRNAs were measured in patients with (n = 6) and without MetS (n = 6) by quantitative PCR array, and dysregulated miRNAs were...

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Bibliographic Details
Published in:Epigenomics 2021-03, Vol.13 (6), p.423-436
Main Authors: Braga, Aécio A, Bortolin, Raul H, Graciano-Saldarriaga, Magda E, Hirata, Thiago Dc, Cerda, Alvaro, de Freitas, Renata Cc, Lin-Wang, Hui T, Borges, Jessica B, França, João Id, Masi, Laureane N, Curi, Rui, Pithon-Curi, Tania C, Sampaio, Marcelo F, Castro, Lara R, Bastos, Gisele M, Hirata, Rosario Dc, Hirata, Mario H
Format: Article
Language:English
Subjects:
adiponectin
Adult
Aged
Aged, 80 and over
Biomarkers - blood
C-Reactive Protein - analysis
circulating miRNAs
Female
Follow-Up Studies
Gene Expression Regulation
Humans
inflammation
Inflammation - blood
Inflammation - etiology
Inflammation - pathology
Insulin Resistance
Male
metabolic syndrome
Metabolic Syndrome - complications
MicroRNAs - blood
MicroRNAs - genetics
Middle Aged
miR-421
obesity
Prognosis
Resistin - blood
Triglycerides - blood
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Summary:To explore the association of circulating miRNAs with adiposity, metabolic status and inflammatory biomarkers in patients with metabolic syndrome (MetS). Serum levels of 372 miRNAs were measured in patients with (n = 6) and without MetS (n = 6) by quantitative PCR array, and dysregulated miRNAs were validated in a larger cohort (MetS, n = 89; non-MetS, n = 144). In the screening study, seven miRNAs were dysregulated in patients with MetS, and miR-421 remained increased in the validation study. miR-421 was associated with a high risk of MetS and insulin resistance and hypertension and correlated with glycated hemoglobin, triacylglycerols, high-sensitivity CRP, IL-6, resistin and adiponectin (p 
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2020-0247