Nuclear Periphery and Telomere Maintenance: TERRA Joins the Stage

Long noncoding (lnc)RNAs derived from telomeres, the ends of linear eukaryotic chromosomes, help to maintain telomere length and stability by multiple means, including regulation of telomerase activity and recombination-based telomere maintenance. New findings in yeast promote a model in which telom...

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Bibliographic Details
Published in:Trends in genetics 2021-07, Vol.37 (7), p.608-611
Main Authors: Juríková, Katarína, De Wulf, Peter, Cusanelli, Emilio
Format: Article
Language:English
Subjects:
budding yeast
fission yeast
nuclear envelope
telomere
telomeric R-loops
TERRA
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Summary:Long noncoding (lnc)RNAs derived from telomeres, the ends of linear eukaryotic chromosomes, help to maintain telomere length and stability by multiple means, including regulation of telomerase activity and recombination-based telomere maintenance. New findings in yeast promote a model in which telomere attachment to the nuclear envelope regulates telomere transcription and maintenance.
ISSN:0168-9525
DOI:10.1016/j.tig.2021.02.003