Therapeutic interventions and mechanisms associated with gut microbiota-mediated modulation of immune checkpoint inhibitor responses

The link between the gut microbiome and responsiveness to immune checkpoint inhibitor (ICI) therapy is now well established. New therapeutic opportunities exploiting this relationship are being developed with the goal of augmenting ICI efficacy. In this review, we summarize the foundational research...

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Bibliographic Details
Published in:Microbes and infection 2021-07, Vol.23 (6-7), p.104804-104804, Article 104804
Main Authors: Wong, Matthew K., Barbulescu, Philip, Coburn, Bryan, Reguera-Nuñez, Elaine
Format: Article
Language:English
Subjects:
Bacterial consortia
Bacterial metabolites
Gut microbiota
Immune checkpoint inhibitor
Immune modulation
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Summary:The link between the gut microbiome and responsiveness to immune checkpoint inhibitor (ICI) therapy is now well established. New therapeutic opportunities exploiting this relationship are being developed with the goal of augmenting ICI efficacy. In this review, we summarize the foundational research establishing these interactions and discuss the mechanisms and novel therapeutic options associated with this gut microbiome-ICI connection.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2021.104804