Diuretic response and effects of diuretic omission in ambulatory heart failure patients on chronic low‐dose loop diuretic therapy

Aims To study loop diuretic response and effect of loop diuretic omission in ambulatory heart failure (HF) patients on chronic low‐dose loop diuretics. Methods and results Urine collections were performed on two consecutive days in 40 ambulatory HF patients with 40–80 mg furosemide (day 1 with loop...

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Bibliographic Details
Published in:European journal of heart failure 2021-07, Vol.23 (7), p.1110-1119
Main Authors: Dauw, Jeroen, Martens, Pieter, Tersalvi, Gregorio, Schouteden, Joren, Deferm, Sébastien, Gruwez, Henri, De Moor, Bart, Nijst, Petra, Dupont, Matthias, Mullens, Wilfried
Format: Article
Language:English
Subjects:
Diuretic response
Heart failure
Loop diuretics
Natriuresis
Urine output
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Summary:Aims To study loop diuretic response and effect of loop diuretic omission in ambulatory heart failure (HF) patients on chronic low‐dose loop diuretics. Methods and results Urine collections were performed on two consecutive days in 40 ambulatory HF patients with 40–80 mg furosemide (day 1 with loop diuretic; day 2 without loop diuretic). Three phases were collected each day: (i) first 6 h; (ii) rest of the day; and (iii) night. On the day of loop diuretic intake, the total natriuresis was 125.9 (86.9–155.0) mmol/24 h and urine output was 1650 (1380–2025) mL/24 h. There was a clear loop diuretic response with a natriuresis of 9.4 (6.7–15.9) mmol/h and a urine output of 117 (83–167) mL/h during the first 6 h, followed by a significant drop in natriuresis and urine output during the rest of the day [2.6 (1.8–4.8) mmol/h and 55 (33–71) mL/h] and night [2.2 (1.6–3.5) mmol/h and 44 (34–73) mL/h]. On day 2, after loop diuretic omission, the natriuresis and urine output remained similarly low the entire day, resulting in a 50% reduction in natriuresis [55.1 (33.5–77.7) mmol/24 h; P 
ISSN:1388-9842
1879-0844
DOI:10.1002/ejhf.2145