Functional Connectomics and Disease Progression in Drug‐Naïve Parkinson's Disease Patients

ABSTRACT Background Functional brain connectivity alterations may be detectable even before the occurrence of brain atrophy, indicating their potential as early markers of pathological processes. Objective We aimed to determine the whole‐brain network topologic organization of the functional connect...

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Published in:Movement disorders 2021-07, Vol.36 (7), p.1603-1616
Main Authors: De Micco, Rosa, Agosta, Federica, Basaia, Silvia, Siciliano, Mattia, Cividini, Camilla, Tedeschi, Gioacchino, Filippi, Massimo, Tessitore, Alessandro
Format: Article
Language:English
Subjects:
Atrophy
Basal ganglia
biomarkers
Brain architecture
Brain mapping
Cognitive ability
connectome
drug‐naïve
functional connectivity
Functional magnetic resonance imaging
Functional morphology
Movement disorders
Neostriatum
Neural networks
Neurodegenerative diseases
Neuroimaging
Parkinson's disease
Patients
Sensorimotor system
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Summary:ABSTRACT Background Functional brain connectivity alterations may be detectable even before the occurrence of brain atrophy, indicating their potential as early markers of pathological processes. Objective We aimed to determine the whole‐brain network topologic organization of the functional connectome in a large cohort of drug‐naïve Parkinson's disease (PD) patients using resting‐state functional magnetic resonance imaging and to explore whether baseline connectivity changes may predict clinical progression. Methods One hundred and forty‐seven drug‐naïve, cognitively unimpaired PD patients were enrolled in the study at baseline and compared to 38 age‐ and gender‐matched controls. Non‐hierarchical cluster analysis using motor and non‐motor data was applied to stratify PD patients into two subtypes: 77 early/mild and 70 early/severe. Graph theory analysis and connectomics were used to assess global and local topological network properties and regional functional connectivity at baseline. Stepwise multivariate regression analysis investigated whether baseline functional imaging data were predictors of clinical progression over 2 years. Results At baseline, widespread functional connectivity abnormalities were detected in the basal ganglia, sensorimotor, frontal, and occipital networks in PD patients compared to controls. Decreased regional functional connectivity involving mostly striato‐frontal, temporal, occipital, and limbic connections differentiated early/mild from early/severe PD patients. Connectivity changes were found to be independent predictors of cognitive progression at 2‐year follow‐up. Conclusions Our findings revealed that functional reorganization of the brain connectome occurs early in PD and underlies crucial involvement of striatal projections. Connectomic measures may be helpful to identify a specific PD patient subtype, characterized by severe motor and non‐motor clinical burden as well as widespread functional connectivity abnormalities. © 2021 International Parkinson and Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.28541