In vivo effects of Viscum album and probiotics against carbon tetrachloride-induced liver injury

This study tested the possible protective and therapeutic effects of Viscum album extract and probiotics against carbon tetrachloride (CCl 4 )-induced acute/chronic liver injury. Male Wistar rats were assigned to seven groups: Control, acute CCl 4 , acute V. album  + CCl 4 , acute V. album  + Probio...

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Bibliographic Details
Published in:Journal of bioenergetics and biomembranes 2021-04, Vol.53 (2), p.139-148
Main Authors: Erdaş, Meltem, Akyüz, Fahrettin, Can, Betül, Özkoç, Mete, Öz, Semih, Dönmez, Dilek Burukoğlu
Format: Article
Language:English
Subjects:
8-Hydroxydeoxyguanosine
Albumins
Animal Anatomy
Animal Biochemistry
Animals
Bilirubin
Biochemistry
Bioorganic Chemistry
Carbon
Carbon tetrachloride
Carbon Tetrachloride - adverse effects
Chemical and Drug Induced Liver Injury, Chronic - drug therapy
Chemistry
Chemistry and Materials Science
Dietary supplements
Disease Models, Animal
Enzymatic activity
Flora
Heme
Histology
Injuries
Intestinal microflora
Intestine
Lipids
Liver
Male
Morphology
Oral administration
Organic Chemistry
Probiotics
Probiotics - pharmacology
Probiotics - therapeutic use
Rats
Rats, Wistar
Viscum album
Viscum album - chemistry
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Summary:This study tested the possible protective and therapeutic effects of Viscum album extract and probiotics against carbon tetrachloride (CCl 4 )-induced acute/chronic liver injury. Male Wistar rats were assigned to seven groups: Control, acute CCl 4 , acute V. album  + CCl 4 , acute V. album  + Probiotics + CCl 4 , chronic CCl 4 , chronic CCl 4  +  V. album , and chronic CCl 4  +  V. album  + Probiotics. Acute and chronic liver injuries were induced by 2 mg/kg CCl 4 (i.p.) and 1 mg/kg CCl 4 (i.p.), respectively. The extract and probiotics were administered daily to related groups. Serum enzyme activities, lipid profile, total protein, albumin, bilirubin, heme oxgenase-1 and 8-hydroxydeoxyguanosine levels were measured. Liver tissue sections stained with Hematoxylin-Eosin. Acute or chronic CCl 4 -exposure caused to significant changes in concentrations/activities of the measured parameters. The oral administration of extract and probiotics showed protective and therapeutic effects against CCl 4 -induced liver-injury. The supplementation of intestinal flora by the use of probiotics may enhance the efficacy of orally given therapeutic extracts.
ISSN:0145-479X
1573-6881
DOI:10.1007/s10863-021-09883-7