Electrochemical Synthesis of Benzimidazoles via Dehydrogenative Cyclization of Amidines

The development of efficient and sustainable methodologies for the synthesis of N‐heterocycles is a constant focus of organic synthesis. Herein an electrochemical method is reported for the synthesis of benzimidazoles through dehydrogenative cyclization of easily available N‐aryl amidines. The react...

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Bibliographic Details
Published in:ChemSusChem 2021-04, Vol.14 (7), p.1692-1695
Main Authors: Zhao, Huai‐Bo, Zhuang, Jin‐Liang, Xu, Hai‐Chao
Format: Article
Language:English
Subjects:
Additives
amidine
Chemical synthesis
C−H functionalization
Dehydrogenation
electrochemical synthesis
oxidation
Oxidizing agents
radical cyclization
Sustainable development
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Summary:The development of efficient and sustainable methodologies for the synthesis of N‐heterocycles is a constant focus of organic synthesis. Herein an electrochemical method is reported for the synthesis of benzimidazoles through dehydrogenative cyclization of easily available N‐aryl amidines. The reactions were conducted under simple constant current conditions in an undivided cell without need for catalysts, chemical oxidants, or additives, and produced H2 as the only theoretical byproduct. Dehydrogenative cyclization: Electrochemical synthesis of benzimidazoles is developed through dehydrogenative cyclization of easily available amidines. The reactions are conducted under neutral conditions without need for chemical oxidants or additives and produce H2 as the byproduct.
ISSN:1864-5631
1864-564X
DOI:10.1002/cssc.202100254