The comparative impact among different intensive statins and combination therapies with niacin/ezetimibe on carotid intima-media thickness: a systematic review, traditional meta-analysis, and network meta-analysis of randomized controlled trials

Purpose To compare the impact of different statins therapies on the reduction of carotid intima-media thickness (CIMT) may reflect their cardiovascular benefits which is useful in clinical decision. Methods PubMed, EMBASE, Cochrane Library, and Web of Science were searched, and 3539 articles publish...

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Published in:European journal of clinical pharmacology 2021-08, Vol.77 (8), p.1133-1145
Main Authors: Li, Hongwei, Xu, Xiaolin, Lu, Liming, Sun, Runlu, Guo, Qi, Chen, Qian, Wang, Junjie, He, Zhijian, Zhang, Yuling
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Clinical trials
Combination therapy
Confidence intervals
Meta-analysis
Nicotinic acid
Pharmacology/Toxicology
Review
Statins
Vitamin B
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Summary:Purpose To compare the impact of different statins therapies on the reduction of carotid intima-media thickness (CIMT) may reflect their cardiovascular benefits which is useful in clinical decision. Methods PubMed, EMBASE, Cochrane Library, and Web of Science were searched, and 3539 articles published from 1992 to 2020 were retrieved. CIMT in randomized controlled trials for statins therapies were included for traditional and network meta-analyses analyzed by Stata 16. The quality of included studies was assessed by the Cochrane Collaboration’s tool. Results Thirty-three randomized controlled trials ( n =8762) were eligible for network meta-analysis, of which 18 randomized controlled trials ( n =5252) were included for comparison between statins and no statins and 11 randomized controlled trials ( n =1338) were included for comparison between high-intensity statins or combination with niacin/ezetimibe and moderate/low-intensity statins in 2 traditional meta-analyses. In the traditional meta-analyses, the statins groups significantly reduce CIMT compared to no statins (standard mean difference=−0.207, 95% confidence interval: −0.291 to −0.123, p
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-021-03113-0