Multifunction in One Molecule: Mitochondrial Imaging and Photothermal & Photodynamic Cytotoxicity of Fast-Response Near-Infrared Fluorescent Probes with Aggregation-Induced Emission Characteristics

HJS and DHJS, two near-infrared emissive and mitochondria-targeted therapy probes, have been designed. They exhibited photothermal & photodynamic cytotoxicity and aggregation-induced emission (AIE) characteristics. Interestingly, we could receive fluorescence immediately after adding the probes...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2021-02, Vol.13 (7), p.7945-7954
Main Authors: Zhang, Lu, Wang, Jiang-Lin, Ba, Xiao-Xu, Hua, Si-Yu, Jiang, Peng, Jiang, Feng-Lei, Liu, Yi
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biological and Medical Applications of Materials and Interfaces
Cell Proliferation - drug effects
Cell Survival - drug effects
Drug Screening Assays, Antitumor
Fluorescent Dyes - chemistry
Fluorescent Dyes - pharmacology
Humans
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Mitochondria - drug effects
Neoplasms, Experimental - diagnostic imaging
Neoplasms, Experimental - drug therapy
Optical Imaging
Particle Size
PC-3 Cells
Photochemotherapy
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - drug therapy
Surface Properties
Tumor Cells, Cultured
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Summary:HJS and DHJS, two near-infrared emissive and mitochondria-targeted therapy probes, have been designed. They exhibited photothermal & photodynamic cytotoxicity and aggregation-induced emission (AIE) characteristics. Interestingly, we could receive fluorescence immediately after adding the probes without washing in 1 min. They could quickly enter cancer cells and selectively localized to the mitochondria firstly. When the concentration of probes was low (
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.0c20283