Janus kinase/signal transducer and activator of transcription signaling pathway-related genes STAT3, SOCS3 and their role in thiram induced tibial dyschondroplasia chickens

Pathogenicity of tibial dyschondroplasia (TD) in broiler chickens is not detected yet. Janus Kinase/Signal Transducer and Activator of Transcription (JAK-STAT) signaling pathway-related genes were investigated in thiram induced TD chickens. Real-time qPCR and immunohistochemical (IHC) technique were...

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Bibliographic Details
Published in:Research in veterinary science 2021-05, Vol.136, p.25-31
Main Authors: Chen, Shu-ming, Jahejo, Ali Raza, Nabi, Fazul, Ahmed, Shakeel, Zhao, Jin-feng, Yu, Jin, Zhang, Chen-liang, Ning, Guan-bao, Zhang, Ding, Raza, Sayed Haidar Abbas, Tian, Wen-xia
Format: Article
Language:English
Subjects:
Apoptosis
Cartilage
Cell cycle
Cell growth
Chicken
Chickens
Chondrocytes
Chondrogenesis
Gene expression
Genes
Growth plate
Histology
JAK/STAT
Janus kinase
Kinases
Localization
Lymphoma
Mineralization
Morphology
p-STAT3
Pathogenicity
Pathogens
Polyclonal antibodies
Poultry
Proteins
Signal transduction
Signaling
SOCS3
Software
Stat3 protein
Thiram
Transcription
Veterinary medicine
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Summary:Pathogenicity of tibial dyschondroplasia (TD) in broiler chickens is not detected yet. Janus Kinase/Signal Transducer and Activator of Transcription (JAK-STAT) signaling pathway-related genes were investigated in thiram induced TD chickens. Real-time qPCR and immunohistochemical (IHC) technique were used to observe the expression changes of STAT3 and SOSC3 gene on days 1, 2, 4, 6 after feeding 100 mg·kg−1 thiram. Morphological, pathological, and histological results of this study suggested that chondrocyte cells were observed more damaged on day 6 than day 1, 2, and 4. Therefore, Lameness and damaged chondrocytes gradually increased from day 1 to 6. The mRNA expression level of STAT3 was observed insignificant (P > 0.05) in thiram induced TD chickens’ group of day 1. However, on days 2, 4, and 6, the expression was significant (P 
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2021.01.024