Neuroendocrine liver metastases: The role of liver transplantation

Neuroendocrine tumor (NET) metastasis localized to the liver is an accepted indication for liver transplantation as such tumors have a low biological aggressiveness in terms of malignancy and are slow growing. The long-term results are comparable with and in some cases even better than those of tran...

Full description

Saved in:

Bibliographic Details
Published in:	Transplantation reviews (Philadelphia, Pa.) Pa.), 2021-04, Vol.35 (2), p.100595-100595, Article 100595
Main Authors:	D'Amico, Giuseppe, Uso, Teresa Diago, Del Prete, Luca, Hashimoto, Koji, Aucejo, Federico N., Fujiki, Masato, Eghtesad, Bijan, Sasaki, Kazunari, David Kwon, Choon H., Miller, Charles M., Quintini, Cristiano
Format:	Article
Language:	eng
Subjects:	Analysis Donation of organs, tissues, etc Gastrointestinal diseases Liver Liver cancer Liver transplantation Metastasis Neuroendocrine liver metastases Outcomes Selection criteria Transplantation
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Neuroendocrine tumor (NET) metastasis localized to the liver is an accepted indication for liver transplantation as such tumors have a low biological aggressiveness in terms of malignancy and are slow growing. The long-term results are comparable with and in some cases even better than those of transplantations performed for primary liver cancer. However, compared with nonmalignant conditions, neuroendocrine liver metastasis (NELM) may result in an inferior outcome of transplantation. In the face of the scarcity of donated organs and recent improved results of non-surgical treatment for NELM, controversy over patient selection and timing for liver transplantation continues. In this review, we provide an overview of the diagnostic work-up and selection criteria of patients with NELM being considered for liver transplantation. Thereafter, we provide a critical analysis of the reported outcomes of OLT. •Compared with nonmalignant conditions, neuroendocrine liver metastasis (NELM) may result in an inferior outcome of transplantation.•OLT provide a survival benefit among patients with NELM who have no evidence of extra-hepatic disease.•Due to high recurrence rates, strict and accurate selection of patients is critical.•Only gastrointestinal tumors with portal drainage can be considered to have the liver as the first destination for metastasis.•The best reported outcomes from surgical NELM treatment appear to be observed in patients undergoing OLT according to Milan selection criteria.
ISSN:	0955-470X 1557-9816