Pattern of occurrence of obsessive-compulsive symptoms in bipolar disorder

•OCS cycle with mood phases with a particular exacerbation in mixed states.•Depression can be involved in the pathogenesis of OCS.•Increased thoughts flow with deficient inhibition may favor the occurrence of OCS.•Mood-stabilization should be the first therapeutic goal in BD-OCD patients. Apparent c...

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Bibliographic Details
Published in:Psychiatry research 2021-03, Vol.297, p.113715-113715, Article 113715
Main Authors: Tonna, Matteo, Trinchieri, Margherita, Lucarini, Valeria, Ferrari, Martina, Ballerini, Massimo, Ossola, Paolo, De Panfilis, Chiara, Marchesi, Carlo
Format: Article
Language:English
Subjects:
Bipolar disorder
Comorbidity
Mixed states
Obsessive-compulsive disorder
Treatment
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Summary:•OCS cycle with mood phases with a particular exacerbation in mixed states.•Depression can be involved in the pathogenesis of OCS.•Increased thoughts flow with deficient inhibition may favor the occurrence of OCS.•Mood-stabilization should be the first therapeutic goal in BD-OCD patients. Apparent comorbidity between Bipolar Disorder (BD) and Obsessive-Compulsive Disorder (OCD) is a common condition, but its meaning has not been clarified yet. The present study aimed to evaluate the pattern of occurrence of obsessive-compulsive symptoms (OCS) in the different phases of BD. One hundred and sixty-five BD patients, 62 (37.5%) euthymic, 34 (20.6%) in hypomanic/manic phase, 43 (26%) in depressive phase and 26 (15.7%) in mixed state, were assessed with the Yale-Brown Obsessive-Compulsive Scale (YBOCS), the Hamilton Depression Rating Scale (HAM-D), the Young Mania Rating Scale (YMRS) and the Ruminative Response Scale (RRS). In the whole sample, the severity of OCS was associated to the severity of depressive symptoms. The highest severity of OCS (YBOCS total score) was observed in the mixed group and the lowest scores in the hypomanic/manic group. Our findings suggest that OCS in BD patients appear as a state-dependent phenomenon cycling with the mood phases, particularly exacerbating in the context of depressive and mixed states.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2021.113715