Prevention of urinary infection through the incorporation of silver–ricinoleic acid–polystyrene nanoparticles on the catheter surface

Nosocominal infections associated with biofilm formation on urinary catheters cause serious complications. The aim of this study was to investigate the feasibility of the polyurethane (PU) catheter modified with tetracycline hydrochloride (TCH) attached Ag nanoparticles embedded PolyRicinoleic acid-...

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Bibliographic Details
Published in:Journal of biomaterials applications 2021-09, Vol.36 (3), p.385-405
Main Authors: Koc, Hazal, Kilicay, Ebru, Karahaliloglu, Zeynep, Hazer, Baki, Denkbas, Emir B
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
Biofilms - drug effects
Catheter-Related Infections - prevention & control
Catheters - adverse effects
Catheters - microbiology
Cell Line
Drug Carriers - chemistry
Escherichia coli - drug effects
Escherichia coli - physiology
Mice
Nanoparticles - chemistry
Polystyrenes - chemistry
Ricinoleic Acids - chemistry
Silver - administration & dosage
Silver - pharmacology
Staphylococcus aureus - drug effects
Staphylococcus aureus - physiology
Urinary Tract Infections - prevention & control
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Summary:Nosocominal infections associated with biofilm formation on urinary catheters cause serious complications. The aim of this study was to investigate the feasibility of the polyurethane (PU) catheter modified with tetracycline hydrochloride (TCH) attached Ag nanoparticles embedded PolyRicinoleic acid-Polystyrene Nanoparticles (PU-TCH-AgNPs-PRici-PS NPs) and the influence on antimicrobial and antibiofilm activity of urinary catheters infected by Escherichia coli and Staphylococcus aureus. For this purpose, AgNPs embedded PRici graft PS graft copolymers (AgNPs-PRici-g-PS) were synthesized via free radical polymerization and characterized by FTIR, HNMR and DSC. AgNPs-PRici-PS NPs were prepared and optimized by the different parameters and the optimized size of nanoparticle was found as about 150 ± 1 nm. The characterization of the nanoparticles and the morphological evaluation were carried out by FTIR and SEM. Short term stability of nanoparticles was realised at 4°C for 30 days. In vitro release profiles of TCH and Ag NPs were also investigated. The formation of biofilm on PU modified TCH-Ag NPs-PRici-PS NPs, was evaluated and the biocompatibility test of the nanoparticles was realized via the mouse fibroblast (L929) and mouse urinary bladder cells (G/G An1). This is the first time that TCH-AgNPs-PRici-PS NPs used in the modification of PU catheter demonstrated high antimicrobial and antibiofilm activities against the urinary tract infection.
ISSN:0885-3282
1530-8022
DOI:10.1177/0885328220983552