Synthesis of Glycodendrimers with Antiviral and Antibacterial Activity

Glycodendrimers are an important class of synthetic macromolecules that can be used to mimic many structural and functional features of cell‐surface glycoconjugates. Their carbohydrate moieties perform key important functions in bacterial and viral infections, often regulated by carbohydrate–protein...

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Bibliographic Details
Published in:Chemistry : a European journal 2021-05, Vol.27 (28), p.7593-7624
Main Authors: Hoyos, Pilar, Perona, Almudena, Juanes, Olga, Rumbero, Ángel, Hernáiz, María J.
Format: Article
Language:English
Subjects:
Adhesion
anti-infection agents
antiadhesion therapy
Antibacterial activity
Avidity
Bacteria
Carbohydrates
carbohydrate–protein interactions
Cell surface
Chemistry
Epitopes
Glycoconjugates
glycodendrimers
Infections
Macromolecules
Molecular structure
Protein interaction
Proteins
Structure-function relationships
Synthesis
Valency
Viral infections
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Summary:Glycodendrimers are an important class of synthetic macromolecules that can be used to mimic many structural and functional features of cell‐surface glycoconjugates. Their carbohydrate moieties perform key important functions in bacterial and viral infections, often regulated by carbohydrate–protein interactions. Several studies have shown that the molecular structure, valency and spatial organisation of carbohydrate epitopes in glycoconjugates are key factors in the specificity and avidity of carbohydrate–protein interactions. Choosing the right glycodendrimers almost always helps to interfere with such interactions and blocks bacterial or viral adhesion and entry into host cells as an effective strategy to inhibit bacterial or viral infections. Herein, the state of the art in the design and synthesis of glycodendrimers employed for the development of anti‐adhesion therapy against bacterial and viral infections is described. Sticky scaffolds: The state of the art in the design and synthesis of glycodendrimers for the development of anti‐adhesion therapy against bacterial and viral infections is described.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202005065