Brain activity alterations in patients with Parkinson’s disease with cognitive impairment based on resting-state functional MRI

The brain regions showed different ReHo values between the PD-CI and PD-NC patients and they revealed that cognitive decline in patients with PD was associated with abnormal spontaneous coherence both in the DMN and the visual network, multiple neurotransmitters and the cerebellum–thalamus–cortex lo...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 2021-03, Vol.747, p.135672-135672, Article 135672
Main Authors: Guo, Weina, Jin, Wei, Li, Na, Gao, Junshu, Wang, Jiuxue, Chang, Yajun, Yin, Kuochang, Chen, Yingmin, Zhang, Shuqian, Wang, Tianjun
Format: Article
Language:English
Subjects:
Cognitive impairment
Parkinson's disease (PD)
regional homogeneity (ReHo)
resting state-fMRI
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The brain regions showed different ReHo values between the PD-CI and PD-NC patients and they revealed that cognitive decline in patients with PD was associated with abnormal spontaneous coherence both in the DMN and the visual network, multiple neurotransmitters and the cerebellum–thalamus–cortex loop. [Display omitted] •Age is a risk factor for cognitive decline in patients with Parkinson’s disease (PD).•The ReHo value of the default mode network (DMN) is closely related to PD cognitive function. The DMN was affected before CI and continuously deteriorated with disease progression.•The disorder of visual conduction pathway is involved in cognitive impairment in patients with PD, and some patients can recruit cognitive resources by improving the efficiency of visual information transmission.•The cognitive function in these patients is related to not only the dopaminergic and cholinergic system but also the noradrenergic system.•The information transmission efficiency of the cerebellum–thalamus–cortex loop was reduced and involved in the cognitive decline process in patients with PD. This study aimed to investigate the differences in regional homogeneity (ReHo) values in patients with Parkinson’s disease (PD) with cognitive impairment (PD-CI) and thus explore the neuropathological mechanism of PD-CI. Resting-state functional magnetic resonance imaging scans were obtained from 36 patients with PD and 20 healthy controls (HCs) in this study. The PD group comprised 20 patients with PD-CI and 16 patients with PD with normal cognitive function (PD-NC). The data were analyzed using ReHo analysis to observe the changes in brain activity in patients with PD-CI and PD-NC. Statistical comparison was performed using covariance analysis and post hoc t tests. The patients in the PD-CI group were older than those in the PD-NC and HC groups. Compared with the HC group, the PD-CI group showed that the ReHo value decreased in the right supplementary motor area, left lingual gyrus, left thalamus, and left precuneus, but increased in the left fusiform gyrus. Compared with the HC group, the PD-NC group showed that the ReHo value decreased in the right cerebellum_6, but increased in the left inferior temporal gyrus, left orbital inferior frontal gyrus, and left precentral gyrus. Compared with the PD-NC group, the PD-CI group showed that the ReHo value decreased in the right precuneus, left triangular inferior frontal gyrus, left middle frontal gyrus, right opercular inferior fr
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2021.135672