Clinical Characteristics and Outcomes of Patients With Takotsubo Syndrome

Characteristics and outcomes of patients with takotsubo syndrome remain to be defined. The goal of this study was to report the characteristics and long-term outcomes of patients presenting with takotsubo syndrome compared with other patients presenting with acute myocardial infarction (AMI) in a co...

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Published in:Canadian journal of cardiology 2021-08, Vol.37 (8), p.1191-1197
Main Authors: Chiu, Sarah, Nayak, Rohith, Lin, Bryan, Duan, Lewei, Shen, Albert Yuh-Jer, Lee, Ming-Sum
Format: Article
Language:English
Subjects:
Age Distribution
Aged
California - epidemiology
Female
Hospitalization
Humans
Hypothyroidism - epidemiology
Lung Diseases - epidemiology
Male
Matched-Pair Analysis
Myocardial Infarction - epidemiology
Retrospective Studies
Rheumatic Diseases - epidemiology
Sex Distribution
Takotsubo Cardiomyopathy - epidemiology
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Summary:Characteristics and outcomes of patients with takotsubo syndrome remain to be defined. The goal of this study was to report the characteristics and long-term outcomes of patients presenting with takotsubo syndrome compared with other patients presenting with acute myocardial infarction (AMI) in a community-based population. This retrospective population-based study included patients hospitalised for AMI from 2006 to 2016. Those patients with takotsubo syndrome were compared with the patients with AMI. The primary outcome was all-cause mortality. Matching was performed to assemble a cohort of patients with similar baseline characteristics. Among 26,015 patients hospitalised with an initial diagnosis of AMI, 530 (2.0%) were diagnosed with takotsubo syndrome. Patients with takotsubo syndrome were older (68.3 ± 11.3 vs 65.6 ± 12.2 years) and more likely to be women (93.4% vs 30.7%). Concomitant hypothyroidism, rheumatologic disorders, and lung disease were more prevalent in the takotsubo syndrome group, whereas diabetes and hyperlipidemia were less prevalent. Mortality was lower in the takotsubo syndrome group (1-year mortality 4.0% vs 8.9%; P < 0.001). The 530 patients with takotsubo syndrome were matched with 1,315 AMI patients with similar baseline characteristics. At a follow-up of 5.4 ± 3.3 years, patients with takotsubo syndrome had a lower risk for all-cause death than other patients who presented with AMI (hazard ratio 0.59, 95% CI 0.47-0.76). Among patients presenting with AMI, patients with takotsubo syndrome were older and more likely to be women. Patients with takotsubo syndrome had better long-term outcomes compared with matched AMI patients. Les caractéristiques et le pronostic des patients atteints du syndrome de Takotsubo restent à définir. L'objectif de cette étude était de rapporter les caractéristiques et le pronostic à long terme des patients présentant un syndrome de Takotsubo par rapport à d'autres patients présentant un infarctus aigu du myocarde (IAM) dans une population à modèle communautaire. Cette étude de population rétrospective comprenait des patients hospitalisés pour un IAM entre 2006 et 2016. Les patients atteints du syndrome de Takotsubo ont été comparés aux patients présentant un IAM. Le principal critère d'évaluation était la mortalité toutes causes confondues. Un appariement a été réalisé pour assembler une cohorte de patients présentant des caractéristiques de référence similaires. Parmi les 26 015 patients hospitalisés av
ISSN:0828-282X
1916-7075
DOI:10.1016/j.cjca.2021.01.014