Podoplanin expression in cancer-associated fibroblasts predicts unfavorable prognosis in node-negative breast cancer patients with hormone receptor-positive/HER2 − negative subtype

Background Podoplanin expression in cancer-associated fibroblasts (CAFs) has been proposed as an indicator for poor prognosis in patients with invasive breast carcinomas, but little is known about its clinical significance in node-negative breast cancer patients with hormone receptor (HR) + /HER2  −...

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Bibliographic Details
Published in:Breast cancer (Tokyo, Japan) Japan), 2021-07, Vol.28 (4), p.822-828
Main Authors: Tanaka, Yuko, Ohno, Takashi, Kadonaga, Taichi, Kidokoro, Yoshiteru, Wakahara, Makoto, Nosaka, Kanae, Sakabe, Tomohiko, Suzuki, Yoshimasa, Nakamura, Hiroshige, Umekita, Yoshihisa
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Antibodies
Biomarkers, Tumor - metabolism
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Cancer patients
Cancer Research
Cancer-Associated Fibroblasts - pathology
Development and progression
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Lymphatic Metastasis
Lymphocytes, Tumor-Infiltrating - pathology
Medicine
Medicine & Public Health
Membrane Glycoproteins - metabolism
Middle Aged
Oncology
Original Article
Progesterone
Prognosis
Receptor, ErbB-2
Retrospective Studies
Surgery
Surgical Oncology
Viral antibodies
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Summary:Background Podoplanin expression in cancer-associated fibroblasts (CAFs) has been proposed as an indicator for poor prognosis in patients with invasive breast carcinomas, but little is known about its clinical significance in node-negative breast cancer patients with hormone receptor (HR) + /HER2  − subtype, who are expected to have a favorable prognosis. Methods Immunohistochemical analyses were performed on 169 resected specimens of node-negative invasive carcinoma of no special type with HR + /HER2 − subtype using antibodies for podoplanin. When more than 10% of CAFs showed immunoreactivity with podoplanin as strong as that of internal positive controls, the specimens were judged as podoplanin-positive. Results Podoplanin-positive status in CAFs was observed in 16.0% (27 of 169 cases) and it associated with high Ki67 labeling index (LI) (> 30%) ( p  = 0.03), higher stromal tumor-infiltrating lymphocytes ( p  
ISSN:1340-6868
1880-4233
DOI:10.1007/s12282-021-01217-0