Study of gut microbiome in Egyptian patients with autoimmune thyroid diseases

Background Hashimoto's thyroiditis (HT) and Graves’ disease (GD) are the most prevalent forms of autoimmune thyroid disorders (ATD). A pathogenic link with gut microbial dysbiosis has been described in different autoimmune disorders but not yet fully elucidated in patients with ATD. Aim of the...

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Bibliographic Details
Published in:International journal of clinical practice (Esher) 2021-05, Vol.75 (5), p.e14038-n/a
Main Authors: El‐Zawawy, Hanaa T., Ahmed, Shwikar M., El‐Attar, Eman A., Ahmed, Asmaa A., Roshdy, Yara S., Header, Doaa A.
Format: Article
Language:English
Subjects:
Autoimmune diseases
Bacteroidetes
Digestive system
Dysbacteriosis
Egypt
Gastrointestinal Microbiome
Graves Disease
Hashimoto Disease
Hashimoto's thyroiditis
Humans
Inflammation
Intestinal microflora
Microbiomes
Microbiota
Probiotics
RNA, Ribosomal, 16S - genetics
rRNA 16S
Thyroid diseases
Thyroid gland
Thyroiditis
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Summary:Background Hashimoto's thyroiditis (HT) and Graves’ disease (GD) are the most prevalent forms of autoimmune thyroid disorders (ATD). A pathogenic link with gut microbial dysbiosis has been described in different autoimmune disorders but not yet fully elucidated in patients with ATD. Aim of the work The present study aimed to elucidate changes in gut microbiome in Egyptian patients with ATD. Patients and Methods The gut bacterial composition of 20 patients with ATD and 30 age, sex, and BMI‐matched healthy subjects as controls was analysed using Quantitative SYBR Green Real‐Time PCR technique targeting 16S rRNA of selected bacterial genera and/or species. Results Compared with controls; the Firmictus/Bacteroidetes ratio (known to be representative for healthy status) was significantly decreased in patients with ATD (P 
ISSN:1368-5031
1742-1241
DOI:10.1111/ijcp.14038