Ultra-low-dose thoracic CT with model-based iterative reconstruction (MBIR) in cystic fibrosis patients undergoing treatment with cystic fibrosis transmembrane conductance regulators (CFTR)

To assess the utility of a volumetric low-dose computed tomography (CT) thorax (LDCTT) protocol at a dose equivalent to a posteroanterior (PA) and lateral chest radiograph for surveillance of cystic fibrosis (CF) patients. A prospective study was undertaken of 19 adult patients with CF that proceede...

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Bibliographic Details
Published in:Clinical radiology 2021-05, Vol.76 (5), p.393.e9-393.e17
Main Authors: Moloney, F., Kavanagh, R.G., Ronan, N.J., Grey, T.M., Joyce, S., Ryan, D.J., Moore, N., O'Connor, O.J., Plant, B.J., Maher, M.M.
Format: Article
Language:English
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Summary:To assess the utility of a volumetric low-dose computed tomography (CT) thorax (LDCTT) protocol at a dose equivalent to a posteroanterior (PA) and lateral chest radiograph for surveillance of cystic fibrosis (CF) patients. A prospective study was undertaken of 19 adult patients with CF that proceeded to LDCTT at 12 and 24 months following initiation of ivacaftor. A previously validated seven-section, low-dose axial CT protocol was used for the 12-month study. A volumetric LDCTT protocol was developed for the 24-month study and reconstructed with hybrid iterative reconstruction (LD-ASIR) and pure iterative reconstruction (model-based IR [LD-MBIR]). Radiation dose was recorded for each scan. Image quality was assessed quantitatively and qualitatively, and disease severity was assessed using a modified Bhalla score. Statistical analysis was performed and p-values of
ISSN:0009-9260
1365-229X
DOI:10.1016/j.crad.2020.12.003