What is the predictive value of intraoperative somatosensory evoked potential monitoring for postoperative neurological deficit in cervical spine surgery?—a meta-analysis

•SSEP monitoring alone is highly specific but weakly sensitive for postoperative neurologic deficit following cervical spine surgery.•Patients with new postoperative neurologic deficits were nearly 27 times more likely to have had significant intraoperative SSEP change.•Loss of SSEP signals and most...

Full description

Saved in:
Bibliographic Details
Published in:The spine journal 2021-04, Vol.21 (4), p.555-570
Main Authors: Reddy, Rajiv P., Chang, Robert, Rosario, Brian P., Sudadi, Shreya, Anetakis, Katherine M., Balzer, Jeffrey R., Crammond, Donald J., Shaw, Jeremy D., Thirumala, Parthasarathy D.
Format: Article
Language:English
Subjects:
Cervical spine fusion and decompression
Diagnostic accuracy
Intraoperative neurophysiological monitoring (IONM)
Meta-analysis
Postoperative neurologic deficit
Somatosensory evoked potential (SSEP)
Spine surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•SSEP monitoring alone is highly specific but weakly sensitive for postoperative neurologic deficit following cervical spine surgery.•Patients with new postoperative neurologic deficits were nearly 27 times more likely to have had significant intraoperative SSEP change.•Loss of SSEP signals and mostly notably, irreversible SSEP changes seem to indicate a much higher risk of injury than reversible SSEP changes.•SSEPs can likely be utilized during cervical spine surgeries to accurately predict the risk of postoperative neurologic deficits. Cervical decompression and fusion surgery remains a mainstay of treatment for a variety of cervical pathologies. Potential intraoperative injury to the spinal cord and nerve roots poses nontrivial risk for consequent postoperative neurologic deficits. Although neuromonitoring with intraoperative somatosensory evoked potentials (SSEPs) is often used in cervical spine surgery, its therapeutic value remains controversial. The purpose of the present study was to evaluate whether significant SSEP changes can predict postoperative neurologic complications in cervical spine surgery. A subgroup analysis was performed to compare the predictive power of SSEP changes in both anterior and posterior approaches. The present study was a meta-analysis of the literature from PubMed, Web of Science, and Embase to identify prospective/retrospective studies with outcomes of patients who underwent cervical spine surgeries with intraoperative SSEP monitoring. The total cohort consisted of 7,747 patients who underwent cervical spine surgery with intraoperative SSEP monitoring. Inclusion criteria for study selection were as follows: (1) prospective or retrospective cohort studies, (2) studies conducted in patients undergoing elective cervical spine surgery not due to aneurysm, tumor, or trauma with intraoperative SSEP monitoring, (3) studies that reported postoperative neurologic outcomes, (4) studies conducted with a sample size ≥20 patients, (5) studies with only adult patients ≥18 years of age, (6) studies published in English, (7) studies inclusive of an abstract. The sensitivity, specificity, diagnostic odds ratio (DOR), and likelihood ratios of overall SSEP changes, reversible SSEP changes, irreversible SSEP changes, and SSEP loss for predicting postoperative neurological deficit were calculated. The total rate of postoperative neurological deficits was 2.50% (194/7,747) and the total rate of SSEP changes was 7.36% (570/7,747). The incidenc
ISSN:1529-9430
1878-1632
DOI:10.1016/j.spinee.2021.01.010