Contrasting association of Helicobacter pylori oipA genotype with risk of peptic ulceration and gastric cancer

Helicobacter pylori OipA (outer inflammatory protein A) is an outer membrane protein that involves in the binding and colonization of the bacterium in the stomach. The oipA status is associated with the risk of peptic ulcerations (PUs) and gastric cancer (GC) diseases. However, the association trend...

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Published in:Infection, genetics and evolution genetics and evolution, 2021-04, Vol.89, p.104720-104720, Article 104720
Main Authors: Feili, Omolbanin, Bakhti, Seyedeh Zahra, Latifi-Navid, Saeid, Zahri, Saber, Yazdanbod, Abbas
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Bacterial Outer Membrane Proteins - genetics
Female
Gastric cancer, peptic ulcerations
Genes, Bacterial
Genotype
H. pylori
Helicobacter pylori - genetics
Humans
Iran
Male
Middle Aged
oipA genotype
Peptic Ulcer - microbiology
Stomach Neoplasms - microbiology
Young Adult
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Summary:Helicobacter pylori OipA (outer inflammatory protein A) is an outer membrane protein that involves in the binding and colonization of the bacterium in the stomach. The oipA status is associated with the risk of peptic ulcerations (PUs) and gastric cancer (GC) diseases. However, the association trend with PUs compared to GC is often different and highly challenging. We therefore aimed to determine the presence of this genotype in Iranian strains and assess its association with the risk of PUs and GC in a larger number of samples. A total of 319 strains were obtained from 172 patients with non-atrophic gastritis (NAG), 52 with PUs and 95 with GC. The prevalence of the oipA+vs. oipA− genotype was 67.7% (216/319). The total frequency of the oipA+vs. oipA− genotypes in NAG, PUs, GC, non-peptic ulceration (including NAG and GC), and non-tumor (including NAG and PUs) groups was 121/172 (70.3%), 50/52 (96.2%), 45/95 (47.4%), 166/267 (62.2%), and 171/224 (76.3%), respectively. In multiple logistic regression analysis, the oipA+vs. oipA− genotype showed a strong direct association with PUs; the ORadj (95% CI) was 18.751 (4.421–79.531), (p = 0.00007). In contrast, it had a significant reverse association with GC; the ORadj (95% CI) was 0.330 (0.179–0.607), (p = 0.00036). In the present study, we interestingly found a contrasting association of the H. pylori oipA genotype with the risk of PUs and GC in Iran. Therefore, the contrasting effect of this genotype may emphasize its independent role in predicting clinical outcomes. •The association of the H. pylori oipA+ genotype with clinical outcomes was assessed in a large number of Iranian H. pylori isolates (N = 319).•The oipA+ genotype was strongly associated with an increased risk of peptic ulcerations (adjusted ORadj = 18.751; p = 0.00007).•The oipA+ genotype significantly reduced the risk of gastric cancer (ORadj = 0.330; p = 0.00036).•The contrasting effect of this genotype may emphasize its independent role in predicting clinical outcomes.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2021.104720