A Subset of Large Cell Neuroendocrine Carcinomas in the Gastroenteropancreatic Tract May Evolve from Pre-existing Well-Differentiated Neuroendocrine Tumors

In the gastro-entero-pancreatic (GEP) tract, neuroendocrine neoplasms (NENs) include well differentiated neuroendocrine tumors (NETs) and high-grade NE carcinomas (NECs), which are thought to make up separate and mutually exclusive tumor entities. Little is known, however, as to whether there may be...

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Bibliographic Details
Published in:Endocrine pathology 2021-09, Vol.32 (3), p.396-407
Main Authors: Pelosi, Giuseppe, Bianchi, Fabrizio, Dama, Elisa, Metovic, Jasna, Barella, Marco, Sonzogni, Angelica, Albini, Adriana, Papotti, Mauro, Gong, Yulan, Vijayvergia, Namrata
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma
Carcinoma, Neuroendocrine - genetics
Carcinoma, Neuroendocrine - pathology
Cluster Analysis
DNA Mutational Analysis
Endocrinology
Female
Humans
Intestinal Neoplasms - genetics
Intestinal Neoplasms - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroendocrine tumors
Neuroendocrine Tumors - genetics
Neuroendocrine Tumors - pathology
Next-generation sequencing
Oncology
Pancreas
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - pathology
Pathology
Prognosis
Sequence analysis
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
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Summary:In the gastro-entero-pancreatic (GEP) tract, neuroendocrine neoplasms (NENs) include well differentiated neuroendocrine tumors (NETs) and high-grade NE carcinomas (NECs), which are thought to make up separate and mutually exclusive tumor entities. Little is known, however, as to whether there may be any pathogenetic link between them. Clustering analysis of a 10-gene panel generated from a previously reported next-generation sequencing analysis on 48 GEP-NENs with clinical annotations was used in the study. Unsupervised cluster analysis showed three histology-independent clusters, namely, C1, C2, and C3, which accounted for 44% of patients but the entire array of mutations. All but two NECs fell into the clusters, yet with different prevalence rates ( p  
ISSN:1046-3976
1559-0097
DOI:10.1007/s12022-020-09659-6