Comparison of acute and chronic effects of Bacopa monnieri, Ginkgo biloba, and Lavandula angustifolia and their mixture on learning and memory in mice

Forty‐seven million people are living with memory‐related disorders worldwide. Phytomedicines are gaining extensive interest in the treatment of these ailments. Memory‐enhancing (acute and chronic) potentials of commercial grade extracts of Bacopa monnieri (200 mg/kg, po), Ginkgo biloba (150 mg/kg,...

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Bibliographic Details
Published in:Phytotherapy research 2021-05, Vol.35 (5), p.2703-2710
Main Authors: Rehman, Mujeeb Ur, Ali, Niaz, Jamal, Muhammad, Kousar, Rehana, Ishaq, Muhammad, Awan, Abdul Aleem, Hussain, Iftekhar, Sherkheli, Muhammad Azhar, ul Haq, Rizwan
Format: Article
Language:English
Subjects:
Amnesia
Animals
Bacopa monnieri
Chronic effects
Ginkgo biloba
Latency
Lavandula angustifolia
mixture
Scopolamine
spatial memory
Synergistic effect
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Summary:Forty‐seven million people are living with memory‐related disorders worldwide. Phytomedicines are gaining extensive interest in the treatment of these ailments. Memory‐enhancing (acute and chronic) potentials of commercial grade extracts of Bacopa monnieri (200 mg/kg, po), Ginkgo biloba (150 mg/kg, po), and Lavandula angustifolia (200 mg/kg, po) and their mixture (B. monnieri 100 mg/kg, G. biloba 75 mg/kg, and L. angustifolia 100 mg/kg, po) were compared for their synergistic/additive effects on the Morris water maze (MWM) test and elevated plus maze (EPM) test in scopolamine‐induced amnesia in mice. Escape latency and accumulative path length were significantly reduced both in acute (up to day 6) and chronic trials (days 8–14) in B. monnieri‐, G. biloba‐, and L. angustifolia‐treated animals and their mixtures (n = 8, p 
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.7016