A novel nanostructured poly(thionine)-deep eutectic solvent/CuO nanoparticle film-modified disposable pencil graphite electrode for determination of acetaminophen in the presence of ascorbic acid

A new electrochemical sensor based on thionine (TH), an electroactive polymer, and CuO nanoparticle (CuONP)-modified pencil graphite electrode (PGE) has been developed. Poly(thionine) (PTH) was formed on the CuO/PGE surface by electropolymerisation in ethaline deep eutectic solvent (DES) containing...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2021-02, Vol.413 (4), p.1149-1157
Main Authors: Dalkiran, Berna, Brett, Christopher M. A.
Format: Article
Language:English
Subjects:
Acetaminophen
Acetic acid
Analgesics
Analysis
Analytical Chemistry
Ascorbic acid
Biochemistry
Characterization and Evaluation of Materials
Chemical sensors
Chemistry
Chemistry and Materials Science
Copper oxide
Copper oxides
Cuprite
Electroactive polymers
Electrochemical analysis
Electrochemical impedance spectroscopy
Electrochemical reactions
Electrochemistry
Electrodes
Fabrication
Food Science
Graphite
Heterocyclic compounds
Identification and classification
Laboratory Medicine
Methods
Monitoring/Environmental Analysis
Nanoparticles
Oxidation
Parameter modification
Parathyroid hormone
Performance enhancement
Polymers
Properties
Reproducibility
Research Paper
Sensors
Solvents
Spectroscopy
Vitamin C
Voltammetry
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Summary:A new electrochemical sensor based on thionine (TH), an electroactive polymer, and CuO nanoparticle (CuONP)-modified pencil graphite electrode (PGE) has been developed. Poly(thionine) (PTH) was formed on the CuO/PGE surface by electropolymerisation in ethaline deep eutectic solvent (DES) containing acetic acid dopant to form PTH Ethaline /CuO/PGE. Cyclic voltammetry, electrochemical impedance spectroscopy, and differential pulse voltammetry were utilized to evaluate the fabrication process, electrochemical properties, and performance parameters of the modified electrodes. The analytical performance of the PTH Ethaline /CuO/PGE was evaluated with respect to linear range, limit of detection, repeatability, and reproducibility for the detection of acetaminophen (APAP) by electrooxidation in the presence of ascorbic acid (AA). Analytical parameters such as pH were optimized. The combined use of PTH and CuONP led to enhanced performance towards APAP due to the large electroactive surface area and synergistic catalytic effect, with a wide linear working range and low detection limit. The reliability of the proposed sensor for the detection of APAP was successfully tested in pharmaceutical samples containing APAP and AA, with very good recoveries. Graphical abstract
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-020-03078-6