Pseudomonas aeruginosa associated with severity of non-cystic fibrosis bronchiectasis measured by the modified bronchiectasis severity score (BSI) and the FACED: The US bronchiectasis and NTM Research Registry (BRR) study

Non-cystic fibrosis bronchiectasis (NCFB) is characterized by dilated bronchi, poor mucus clearance and susceptibility to bacterial infection. Pseudomonas aeruginosa (PA) is one of the most frequently isolated pathogens in patients with NCFB. The purpose of this study was to evaluate the association...

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Published in:Respiratory medicine 2021-02, Vol.177, p.106285-106285, Article 106285
Main Authors: Choate, Radmila, Aksamit, Timothy R., Mannino, David, Addrizzo-Harris, Doreen, Barker, Alan, Basavaraj, Ashwin, Daley, Charles L., Daniels, M. Leigh Anne, Eden, Edward, DiMango, Angela, Fennelly, Kevin, Griffith, David E., Johnson, Margaret M., Knowles, Michael R., McShane, Pamela J., Metersky, Mark L., Noone, Peadar G., O'Donnell, Anne E., Olivier, Kenneth N., Salathe, Matthias A., Schmid, Andreas, Thomashow, Byron, Tino, Gregory, Winthrop, Kevin L., Stone, Glenda
Format: Article
Language:English
Subjects:
Age
Bacterial diseases
Bacterial infections
Bronchi
Bronchiectasis
Bronchiectasis severity
Bronchodilators
Bronchus
Chronic illnesses
Cystic fibrosis
Data collection
Disease
Dyspnea
Evaluation
Hospitalization
Infections
Medical records
Microorganisms
Mortality
Mucus
Non-cystic fibrosis bronchiectasis
Patients
Pseudomonas aeruginosa
Quality of life
Registry
Regression analysis
Severity scores
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Summary:Non-cystic fibrosis bronchiectasis (NCFB) is characterized by dilated bronchi, poor mucus clearance and susceptibility to bacterial infection. Pseudomonas aeruginosa (PA) is one of the most frequently isolated pathogens in patients with NCFB. The purpose of this study was to evaluate the association between presence of PA and disease severity in patients within the US Bronchiectasis and Nontuberculous mycobacteria (NTM) Research Registry (BRR). Baseline US BRR data from adult patients with NCFB collected between 2008 and 2018 was used for this study. The presence of PA was defined as one or more positive PA cultures within two years prior to enrollment. Modified Bronchiectasis Severity Index (m-BSI) and modified FACED (m-FACED) were computed to evaluate severity of bronchiectasis. Unadjusted and multivariable multinomial regression models were used to assess the association between presence of PA and severity of bronchiectasis. Average age of the study participants (n = 1831) was 63.7 years (SD = 14.1), 91.5% white, and 78.8% female. Presence of PA was identified in 25.4% of the patients. Patients with presence of PA had significantly lower mean pre-bronchodilator FEV1% predicted compared to those without PA (62.8% vs. 73.7%, p 
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2020.106285