Polyacrylonitrile-based carbon nanofibers as a matrix for laser desorption/ionization time-of-flight mass spectrometric analysis of small molecules under both positive and negative ionization modes

Carbon fiber (CNF), prepared by carbonization of electrospun polyacrylonitrile (PAN) fibers, is systematically investigated as a mediator to replace conventional organic matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS). CNF exhibits a high salt tol...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2021-02, Vol.413 (4), p.1193-1202
Main Authors: Chae, Ari, Lee, Gwanwon, Koh, Dong-Yeun, Yang, Cheol-Min, Lee, Sungho, Kim, Young-Kwan
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Carbohydrates
Carbon fiber reinforced plastics
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Desorption
Food Science
Ionization
Ions
Laboratory Medicine
Lasers
Mass spectrometry
Mass spectroscopy
Methods
Monitoring/Environmental Analysis
Nanofibers
Nanotubes
Polyacrylonitrile
Research Paper
Saccharides
Salinity tolerance
Salt tolerance
Scientific imaging
Spectroscopy
Time-of-flight mass spectrometry
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Summary:Carbon fiber (CNF), prepared by carbonization of electrospun polyacrylonitrile (PAN) fibers, is systematically investigated as a mediator to replace conventional organic matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS). CNF exhibits a high salt tolerance, sensitivity, and resolution for organic matrix-free laser desorption/ionization time-of-flight mass spectrometry (LDI-MS) analysis of various analytes under both positive and negative ionization modes. Especially, saccharides, a neutral molecule having low negative ionization efficiency, are successfully detected with CNF. Taken together, this study clearly demonstrates CNF is a promising material to develop an efficient and universal platform for LDI-MS analysis regardless of preferential ionization modes of analytes. Graphical abstract
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-020-03083-9